TY - JOUR
T1 - Effect of interpregnancy interval on outcomes of pregnancy after recurrent pregnancy loss
AU - Bentolila, Yaara
AU - Ratzon, Ronit
AU - Shoham-Vardi, Ilana
AU - Serjienko, Ruslan
AU - Mazor, Moshe
AU - Bashiri, Asher
PY - 2013/9/1
Y1 - 2013/9/1
N2 - Objective: To examine the effect of interpregnancy interval (IPI) on outcomes of pregnancy after recurrent pregnancy loss (RPL). Methods: A retrospective cohort study including 325 patients treated at a RPL clinic, with two or more consecutive pregnancy losses followed by a subsequent (index) pregnancy, of whom 163 had IPI ≤ 6 months, and 212 had IPI > 6 months. Results: Pregnancy loss rate in the index pregnancy was positively associated with increased IPI (18.6% in women with IPI ≤ 6 months, and 29.7% in women with IPI > 6 months; p = 0.029). In a multivariable logistic analysis, excluding women with fertility problems, and adjusting for maternal age and ethnicity, the OR for pregnancy loss rate for IPI longer than 6 months compared to shorter IPI was 1.76 (95%CI: 0.96-3.22, p = 0.067). Conclusions: Our results suggest that IPI shorter than 6 months, in women with no fertility problems, is associated with lower rate of subsequent miscarriage. Further studies are needed to substantiate this finding.
AB - Objective: To examine the effect of interpregnancy interval (IPI) on outcomes of pregnancy after recurrent pregnancy loss (RPL). Methods: A retrospective cohort study including 325 patients treated at a RPL clinic, with two or more consecutive pregnancy losses followed by a subsequent (index) pregnancy, of whom 163 had IPI ≤ 6 months, and 212 had IPI > 6 months. Results: Pregnancy loss rate in the index pregnancy was positively associated with increased IPI (18.6% in women with IPI ≤ 6 months, and 29.7% in women with IPI > 6 months; p = 0.029). In a multivariable logistic analysis, excluding women with fertility problems, and adjusting for maternal age and ethnicity, the OR for pregnancy loss rate for IPI longer than 6 months compared to shorter IPI was 1.76 (95%CI: 0.96-3.22, p = 0.067). Conclusions: Our results suggest that IPI shorter than 6 months, in women with no fertility problems, is associated with lower rate of subsequent miscarriage. Further studies are needed to substantiate this finding.
KW - Birth rate
KW - Index pregnancy
KW - Interpregnancy interval
KW - Perinatal mortality
KW - Pregnancy complications
KW - Pregnancy outcomes
KW - Recurrent miscarriage
KW - Recurrent pregnancy loss
UR - http://www.scopus.com/inward/record.url?scp=84882328401&partnerID=8YFLogxK
U2 - 10.3109/14767058.2013.784264
DO - 10.3109/14767058.2013.784264
M3 - Article
C2 - 23488821
AN - SCOPUS:84882328401
VL - 26
SP - 1459
EP - 1464
JO - Journal of Maternal-Fetal and Neonatal Medicine
JF - Journal of Maternal-Fetal and Neonatal Medicine
SN - 1476-7058
IS - 14
ER -