Effect of lysine vasopressin in depressed patients on mood and 24-hour rhythm of growth hormone, cortisol, melatonin and prolactin

Joseph Zohar, Dov Drummer, E. D. Edelstein, Nurit Kaiser, Robert H. Belmaker, Isaac Nir

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Lysine-8-vasopressin (LVP) for 10 days and in doses up to 13.5 LVP units did not significantly alter the Hamilton Depression Rating Scale scores of 12 severely depressed, treatment-resistant patients who were evaluated in a double-blind crossover study. The 24-h rhythms of melatonin, cortisol, growth hormone and prolactin appeared remarkably stable over the course of repeated measurement. LVP administration did not affect these 24-h rhythms.

Original languageEnglish
Pages (from-to)273-279
Number of pages7
JournalPsychoneuroendocrinology
Volume10
Issue number3
DOIs
StatePublished - 1 Jan 1985
Externally publishedYes

Keywords

  • 24-h rhythm
  • Lysine vasopressin
  • cortisol
  • growth hormone
  • melatonin
  • prolactin
  • resistant depression

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