Effect of moderate alcohol intake on patients with type 2 diabetes; multi-center, randomised, diet-controlled intervention study

Iris Shai, J. Vainstein, Ilana Harman-Boehm, Itamar Raz, Assaf Rudich, M. Stampfer

Research output: Contribution to journalMeeting Abstract


Introduction: Recent studies suggest that diabetic patients may benefit from
the effects of moderate alcohol consumption, but the glycemic effects of such
intervention are unclear. Using an interventional approach, we aimed to
address the effect of daily moderate alcohol intake on glycemic control in the
fasting and postprandial states in type 2 diabetic abstainers, and to determine
adverse effects of such intervention.
Methods: One hundred and nine abstainer patients (41–74 yrs old) with
established type 2 diabetes were randomised to receive 150 ml wine
(intervention) or non-alcoholic diet beer (control) during 3 months of a dietcontrolled, multi-center randomized intervention trial. The beverages were
consumed during dinner. Diet and alcohol consumption were monitored.
Results: Within the alcohol intervention group, fasting plasma glucose (FPG)
decreased from 139.58mg/dL+/–41.0 to 118.01+/– 32.5) after 3 months
(Delta=–21.55mg/dL, Pv=0.015 as compared to delta of the controls).
However, alcohol consumption had no effect on 2-hour postprandial glucose
levels (Pv=0.966). Patients in the intervention group with higher baseline HbA1c levels had greater reduction in FPG (age-adjusted correlation= –0.33,
Pv= 0.045). No significant changes were observed in the levels of Bilirubin,
Alkaline Phosphatases, ALT or AST, nor were their reported adverse effects.
However, participants in the intervention group reported an improvement in
the ability to fall asleep (Pv=0.001 as compared to the controls).
Conclusions: Among abstainers who are type 2 diabetic, initiation of
moderate daily alcohol consumption results in decreased FPG but not
post-meal glucose. Patients with higher HbA1c may benefit more from the
favorable effect of alcohol on glycemic control. Longer studies are needed to
determine the efficacy of initiating consumption of moderate alcohol intake
among abstainers with type 2 diabetes.
Original languageEnglish
Pages (from-to)S66-S67
Number of pages2
StatePublished - 1 Sep 2007


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