Effect of mouse interferon on retrovirus production by chronically infected rat cells

Mahmoud Huleihel; Mordechai Aboud

doi:10.1016/0166-3542(82)90019-5

Effect of mouse interferon on retrovirus production by chronically infected rat cells

Mahmoud Huleihel, Mordechai Aboud

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Mouse interferon (IFN) inhibited retrovirus release by both mouse and rat cells with the same efficiency. However, the antiviral state developed more slowly in rat than in mouse cells, and after removal of IFN it also persisted for a longer time in rat than in mouse cells. Under conditions where IFN strongly inhibited virus production it had no effect on cell replication nor on cellular RNA or protein synthesis.

Original language	English
Pages (from-to)	167-175
Number of pages	9
Journal	Antiviral Research
Volume	2
Issue number	3
DOIs	https://doi.org/10.1016/0166-3542(82)90019-5
State	Published - 1 Jan 1982

Keywords

interferon
retroviruses
reverse transcriptase

ASJC Scopus subject areas

Pharmacology
Virology

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10.1016/0166-3542(82)90019-5

Cite this

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title = "Effect of mouse interferon on retrovirus production by chronically infected rat cells",

abstract = "Mouse interferon (IFN) inhibited retrovirus release by both mouse and rat cells with the same efficiency. However, the antiviral state developed more slowly in rat than in mouse cells, and after removal of IFN it also persisted for a longer time in rat than in mouse cells. Under conditions where IFN strongly inhibited virus production it had no effect on cell replication nor on cellular RNA or protein synthesis.",

keywords = "interferon, retroviruses, reverse transcriptase",

author = "Mahmoud Huleihel and Mordechai Aboud",

note = "Funding Information: This study was supported by a grant from the Chernow and Strein Foundation of the Israel Cancer Research Fund, New York, U.S.A.",

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AU - Huleihel, Mahmoud

AU - Aboud, Mordechai

N1 - Funding Information: This study was supported by a grant from the Chernow and Strein Foundation of the Israel Cancer Research Fund, New York, U.S.A.

PY - 1982/1/1

Y1 - 1982/1/1

N2 - Mouse interferon (IFN) inhibited retrovirus release by both mouse and rat cells with the same efficiency. However, the antiviral state developed more slowly in rat than in mouse cells, and after removal of IFN it also persisted for a longer time in rat than in mouse cells. Under conditions where IFN strongly inhibited virus production it had no effect on cell replication nor on cellular RNA or protein synthesis.

AB - Mouse interferon (IFN) inhibited retrovirus release by both mouse and rat cells with the same efficiency. However, the antiviral state developed more slowly in rat than in mouse cells, and after removal of IFN it also persisted for a longer time in rat than in mouse cells. Under conditions where IFN strongly inhibited virus production it had no effect on cell replication nor on cellular RNA or protein synthesis.

KW - interferon

KW - retroviruses

KW - reverse transcriptase

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U2 - 10.1016/0166-3542(82)90019-5

DO - 10.1016/0166-3542(82)90019-5

M3 - Article

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ER -

Effect of mouse interferon on retrovirus production by chronically infected rat cells

Abstract

Keywords

ASJC Scopus subject areas

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