Effect of mutators on adaptability in time-varying fitness landscapes

Pavel Gorodetsky, Emmanuel Tannenbaum

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


This Brief Report studies the quasispecies dynamics of a population capable of genetic repair evolving on a time-dependent fitness landscape. We develop a model that considers an asexual population of single-stranded, conservatively replicating genomes, whose only source of genetic variation is due to copying errors during replication. We consider a time-dependent, single-fitness-peak landscape where the master sequence changes by a single point mutation at every time τ. We are able to analytically solve for the evolutionary dynamics of the population in the point-mutation limit. In particular, our model provides an analytical expression for the fraction of mutators in the dynamic fitness landscape that agrees well with results from stochastic simulations.

Original languageEnglish
Article number042901
JournalPhysical Review E
Issue number4
StatePublished - 10 Apr 2008

ASJC Scopus subject areas

  • Statistical and Nonlinear Physics
  • Statistics and Probability
  • Condensed Matter Physics


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