Effect of Narp deletion on neophobia

A Blouin, J A Lee, B Tao, A Johnson, D Smith, J Baraban, I M Reti

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Neuronal activity regulated pentraxin, or Narp, is a secreted immediate early gene product that clusters AMPA receptors. We have previously shown that Narp knockout (KO) mice display extinction deficits in a morphine conditioned place preference paradigm. Studies suggest that both animals and humans who display addictive behavior also show increased novelty-seeking, although this association is complex and contradictory evidence exists. We sought to determine whether Narp KO mice, which display increased morphine craving, also display increased novelty-seeking. Methods: To assess reactivity to novelty, Narp KO mice and littermate wild-type (WT) controls were tested on a neophobia paradigm. Firstly, mice were singly housed and habituated to a liquid rodent diet over 1 week that was available ad libitum. The following week, presentation of the diet was restricted to two hours in the morning and one hour in the afternoon. On days 3, 5 and 8, instead of receiving the liquid diet over one hour in the afternoon, mice were presented with a 3% decaffeinated coffee solution. Results: Both Narp KO and WT control mice demonstrated neophobia to the coffee solution but did not significantly differ in their consumption of the coffee solution at initial exposure on day 3. However, Narp KO mice demonstrated impaired recovery from neophobia, drinking less than WT mice on exposure to the coffee solution on day 5 (p
Original languageEnglish
Pages (from-to)S133
JournalNeuropsychopharmacology
Volume38
StatePublished - 2012

Keywords

  • AMPA receptor
  • Student t test
  • addiction
  • alpha amino 3 hydroxy 5 methyl 4 isoxazolepropioni
  • coffee
  • college
  • diet
  • drinking
  • exposure
  • gene product
  • human
  • immediate early gene
  • knockout mouse
  • learning
  • liquid
  • morphine
  • mouse
  • mouse mutant
  • neophobia
  • pentraxin
  • place preference
  • psychopharmacology
  • rodent
  • wild type
  • withdrawal syndrome

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