Effect of persistent measles virus infection on protein kinase C activity and c-fos protooncogene expression in neuroblastoma cells

M. Wolfson; A. Katorza; S. Segal; B. Rager-Zisman

doi:10.1016/0014-5793(89)80757-4

Effect of persistent measles virus infection on protein kinase C activity and c-fos protooncogene expression in neuroblastoma cells

M. Wolfson, A. Katorza, S. Segal, B. Rager-Zisman

The Shraga Segal Department of Microbiology, Immunology and Genetics

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

The effect of persistent measles virus infection on c-fos protooncogene and protein kinase C (PKC-I) gene expression in a murine neuroblastoma cell line was studied. Overexpression of c-fos protooncogene by infected NS20Y/MS cells was detected when compared with uninfected NS20Y cells. The level of PKC-I-specific mRNA was increased in infected NS20Y/MS cells. In addition, the level of total PKC activity in these cells was also enhanced. We conclude that persistent measles virus infection can alter both protooncogene expression and signal transduction in cells of neuronal origin.

Original language	English
Pages (from-to)	367-370
Number of pages	4
Journal	FEBS Letters
Volume	250
Issue number	2
DOIs	https://doi.org/10.1016/0014-5793(89)80757-4
State	Published - 3 Jul 1989

Keywords

(Murine neuroblastoma C1300)
Protein kinase C
Protooncogene, c-fos

ASJC Scopus subject areas

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics
Cell Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/0014-5793(89)80757-4

Cite this

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title = "Effect of persistent measles virus infection on protein kinase C activity and c-fos protooncogene expression in neuroblastoma cells",

abstract = "The effect of persistent measles virus infection on c-fos protooncogene and protein kinase C (PKC-I) gene expression in a murine neuroblastoma cell line was studied. Overexpression of c-fos protooncogene by infected NS20Y/MS cells was detected when compared with uninfected NS20Y cells. The level of PKC-I-specific mRNA was increased in infected NS20Y/MS cells. In addition, the level of total PKC activity in these cells was also enhanced. We conclude that persistent measles virus infection can alter both protooncogene expression and signal transduction in cells of neuronal origin.",

keywords = "(Murine neuroblastoma C1300), Protein kinase C, Protooncogene, c-fos",

author = "M. Wolfson and A. Katorza and S. Segal and B. Rager-Zisman",

note = "Funding Information: Acknowledgements: We thank Dr I. Weinstein for providing us with PKC-I cDNA probe. This research was supported in part by grants from the Israel Institute of Psychobiology and from the Chief Scientist, Israel Ministry of Health. B.R.Z. is a recipient of a Career Development Award, Israel Cancer Research Fund, New York, USA.",

year = "1989",

month = jul,

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doi = "10.1016/0014-5793(89)80757-4",

language = "English",

volume = "250",

pages = "367--370",

journal = "FEBS Letters",

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publisher = "John Wiley and Sons Inc.",

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TY - JOUR

T1 - Effect of persistent measles virus infection on protein kinase C activity and c-fos protooncogene expression in neuroblastoma cells

AU - Wolfson, M.

AU - Katorza, A.

AU - Segal, S.

AU - Rager-Zisman, B.

N1 - Funding Information: Acknowledgements: We thank Dr I. Weinstein for providing us with PKC-I cDNA probe. This research was supported in part by grants from the Israel Institute of Psychobiology and from the Chief Scientist, Israel Ministry of Health. B.R.Z. is a recipient of a Career Development Award, Israel Cancer Research Fund, New York, USA.

PY - 1989/7/3

Y1 - 1989/7/3

N2 - The effect of persistent measles virus infection on c-fos protooncogene and protein kinase C (PKC-I) gene expression in a murine neuroblastoma cell line was studied. Overexpression of c-fos protooncogene by infected NS20Y/MS cells was detected when compared with uninfected NS20Y cells. The level of PKC-I-specific mRNA was increased in infected NS20Y/MS cells. In addition, the level of total PKC activity in these cells was also enhanced. We conclude that persistent measles virus infection can alter both protooncogene expression and signal transduction in cells of neuronal origin.

AB - The effect of persistent measles virus infection on c-fos protooncogene and protein kinase C (PKC-I) gene expression in a murine neuroblastoma cell line was studied. Overexpression of c-fos protooncogene by infected NS20Y/MS cells was detected when compared with uninfected NS20Y cells. The level of PKC-I-specific mRNA was increased in infected NS20Y/MS cells. In addition, the level of total PKC activity in these cells was also enhanced. We conclude that persistent measles virus infection can alter both protooncogene expression and signal transduction in cells of neuronal origin.

KW - (Murine neuroblastoma C1300)

KW - Protein kinase C

KW - Protooncogene, c-fos

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U2 - 10.1016/0014-5793(89)80757-4

DO - 10.1016/0014-5793(89)80757-4

M3 - Article

AN - SCOPUS:0024361292

SN - 0014-5793

VL - 250

SP - 367

EP - 370

JO - FEBS Letters

JF - FEBS Letters

IS - 2

ER -

Effect of persistent measles virus infection on protein kinase C activity and c-fos protooncogene expression in neuroblastoma cells

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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