Effect of persistent measles virus infection on protein kinase C activity and c-fos protooncogene expression in neuroblastoma cells

M. Wolfson, A. Katorza, S. Segal, B. Rager-Zisman

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

The effect of persistent measles virus infection on c-fos protooncogene and protein kinase C (PKC-I) gene expression in a murine neuroblastoma cell line was studied. Overexpression of c-fos protooncogene by infected NS20Y/MS cells was detected when compared with uninfected NS20Y cells. The level of PKC-I-specific mRNA was increased in infected NS20Y/MS cells. In addition, the level of total PKC activity in these cells was also enhanced. We conclude that persistent measles virus infection can alter both protooncogene expression and signal transduction in cells of neuronal origin.

Original languageEnglish
Pages (from-to)367-370
Number of pages4
JournalFEBS Letters
Volume250
Issue number2
DOIs
StatePublished - 3 Jul 1989

Keywords

  • (Murine neuroblastoma C1300)
  • Protein kinase C
  • Protooncogene, c-fos

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