Effect of prolonged use of inhaled steroids on the cellular immunity of children with asthma

Jacov Levy; Irina Zalkinder; Oded Kuperman; Agneta Skibin; Ron Apte; Jacob E. Bearman; Paul W. Mielke; Asher Tal

doi:10.1016/S0091-6749(95)70122-2

Effect of prolonged use of inhaled steroids on the cellular immunity of children with asthma

Jacov Levy, Irina Zalkinder, Oded Kuperman, Agneta Skibin, Ron Apte, Jacob E. Bearman, Paul W. Mielke, Asher Tal

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Background: Systemic corticosteroids may affect the cellular immunity, but there is no available controlled data on such effects associated with a prolonged use of inhaled corticosteroids. Objective: The investigation was designed to study the effect of long-term inhaled beclomethasone dipropionate in daily doses of up to 600 μg on cellular immune functions. Methods: Twenty-four children with asthma treated with inhaled beclomethasone dipropionate for a mean of 22.6 months were compared with 16 children with asthma not treated with an inhaled steroid and with 20 healthy adults. Cellular immune parameters included differential white blood count, T- and B-cell numbers, T helper and suppressor counts, T-cell mitogenic transformation, and interleukin-1 and interleukin-2 secretion. Results: There was no difference in any of the studied cellular immune functions among the three study groups. Conclusion: Long-term use of inhaled beclomethasone dipropionate by children with asthma, at daily doses of up to 600 μg, has no effect on certain parameters of cellular immunity. (J ALLERGY CLIN IMMUNOL 1995;95:806-12.).

Original language	English
Pages (from-to)	806-812
Number of pages	7
Journal	The Journal of Allergy and Clinical Immunology
Volume	95
Issue number	4
DOIs	https://doi.org/10.1016/S0091-6749(95)70122-2
State	Published - 1 Jan 1995
Externally published	Yes

Keywords

Corticosteroids
asthma
beclomethasone dipropionate
cellular immunity

ASJC Scopus subject areas

Immunology and Allergy
Immunology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/S0091-6749(95)70122-2

Cite this

@article{699236b0508346ebb9b6bf220876745c,

title = "Effect of prolonged use of inhaled steroids on the cellular immunity of children with asthma",

abstract = "Background: Systemic corticosteroids may affect the cellular immunity, but there is no available controlled data on such effects associated with a prolonged use of inhaled corticosteroids. Objective: The investigation was designed to study the effect of long-term inhaled beclomethasone dipropionate in daily doses of up to 600 μg on cellular immune functions. Methods: Twenty-four children with asthma treated with inhaled beclomethasone dipropionate for a mean of 22.6 months were compared with 16 children with asthma not treated with an inhaled steroid and with 20 healthy adults. Cellular immune parameters included differential white blood count, T- and B-cell numbers, T helper and suppressor counts, T-cell mitogenic transformation, and interleukin-1 and interleukin-2 secretion. Results: There was no difference in any of the studied cellular immune functions among the three study groups. Conclusion: Long-term use of inhaled beclomethasone dipropionate by children with asthma, at daily doses of up to 600 μg, has no effect on certain parameters of cellular immunity. (J ALLERGY CLIN IMMUNOL 1995;95:806-12.).",

keywords = "Corticosteroids, asthma, beclomethasone dipropionate, cellular immunity",

author = "Jacov Levy and Irina Zalkinder and Oded Kuperman and Agneta Skibin and Ron Apte and Bearman, {Jacob E.} and Mielke, {Paul W.} and Asher Tal",

year = "1995",

month = jan,

day = "1",

doi = "10.1016/S0091-6749(95)70122-2",

language = "English",

volume = "95",

pages = "806--812",

journal = "The Journal of Allergy and Clinical Immunology",

issn = "0091-6749",

publisher = "Elsevier Inc.",

number = "4",

}

TY - JOUR

T1 - Effect of prolonged use of inhaled steroids on the cellular immunity of children with asthma

AU - Levy, Jacov

AU - Zalkinder, Irina

AU - Kuperman, Oded

AU - Skibin, Agneta

AU - Apte, Ron

AU - Bearman, Jacob E.

AU - Mielke, Paul W.

AU - Tal, Asher

PY - 1995/1/1

Y1 - 1995/1/1

N2 - Background: Systemic corticosteroids may affect the cellular immunity, but there is no available controlled data on such effects associated with a prolonged use of inhaled corticosteroids. Objective: The investigation was designed to study the effect of long-term inhaled beclomethasone dipropionate in daily doses of up to 600 μg on cellular immune functions. Methods: Twenty-four children with asthma treated with inhaled beclomethasone dipropionate for a mean of 22.6 months were compared with 16 children with asthma not treated with an inhaled steroid and with 20 healthy adults. Cellular immune parameters included differential white blood count, T- and B-cell numbers, T helper and suppressor counts, T-cell mitogenic transformation, and interleukin-1 and interleukin-2 secretion. Results: There was no difference in any of the studied cellular immune functions among the three study groups. Conclusion: Long-term use of inhaled beclomethasone dipropionate by children with asthma, at daily doses of up to 600 μg, has no effect on certain parameters of cellular immunity. (J ALLERGY CLIN IMMUNOL 1995;95:806-12.).

AB - Background: Systemic corticosteroids may affect the cellular immunity, but there is no available controlled data on such effects associated with a prolonged use of inhaled corticosteroids. Objective: The investigation was designed to study the effect of long-term inhaled beclomethasone dipropionate in daily doses of up to 600 μg on cellular immune functions. Methods: Twenty-four children with asthma treated with inhaled beclomethasone dipropionate for a mean of 22.6 months were compared with 16 children with asthma not treated with an inhaled steroid and with 20 healthy adults. Cellular immune parameters included differential white blood count, T- and B-cell numbers, T helper and suppressor counts, T-cell mitogenic transformation, and interleukin-1 and interleukin-2 secretion. Results: There was no difference in any of the studied cellular immune functions among the three study groups. Conclusion: Long-term use of inhaled beclomethasone dipropionate by children with asthma, at daily doses of up to 600 μg, has no effect on certain parameters of cellular immunity. (J ALLERGY CLIN IMMUNOL 1995;95:806-12.).

KW - Corticosteroids

KW - asthma

KW - beclomethasone dipropionate

KW - cellular immunity

UR - http://www.scopus.com/inward/record.url?scp=0028948740&partnerID=8YFLogxK

U2 - 10.1016/S0091-6749(95)70122-2

DO - 10.1016/S0091-6749(95)70122-2

M3 - Article

AN - SCOPUS:0028948740

SN - 0091-6749

VL - 95

SP - 806

EP - 812

JO - The Journal of Allergy and Clinical Immunology

JF - The Journal of Allergy and Clinical Immunology

IS - 4

ER -

Effect of prolonged use of inhaled steroids on the cellular immunity of children with asthma

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this