Effect of single dose methylphenidate on walking and postural stability under single- and dual-task conditions in older adults - A double-blind randomized control trial

Zamir Shorer, Yaakov Bachner, Tal Guy, Itshak Melzer

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Background. Methylphenidate (MPH) action may improve executive function and motor function. Effects of MPH on balance function in older adults were investigated.Methods. A randomized controlled double-blind study examined the effects of a single dose of MPH on gait and postural stability in 30 healthy older adults (mean age = 74.9 ± 5.6) in four task conditions: (a) single task, standing still; (b) dual task, standing still performing a memory task; (c) single task, narrow base walking; and (d) dual task, narrow base walking, performing concurrent cognitive tasks.Results. A single dose of MPH improved narrow base walking by reducing the number of step errors and step error rate in both single and dual tasks, with no equivalent improvement in postural stability.Conclusions. A single dose of MPH was able to improve gait function in older adults, especially in complex dual tasks that require higher executive control. This could largely account for the effects of MPH on a sustained attention dual task, but direct effects on the motor system may have also played a role.

Original languageEnglish
Pages (from-to)1271-1280
Number of pages10
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume68
Issue number10
DOIs
StatePublished - 1 Oct 2013

Keywords

  • Dual task.
  • Elderly adults
  • Gait
  • Methylphenidate
  • Postural stability
  • Single task

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology

Fingerprint

Dive into the research topics of 'Effect of single dose methylphenidate on walking and postural stability under single- and dual-task conditions in older adults - A double-blind randomized control trial'. Together they form a unique fingerprint.

Cite this