Effect of synthetic enantiomeric cannabinoids on platelet aggregation

I. Nathan, G. Agam, R. Mechoulam, A. Dvilansky, A. A. Livne

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

The effect of a synthetic pair of enantiomeric cannabinoids on platelet function was evaluated. The nonpsychotropic enantiomer, the 1,1-dimethylheptyl homolog of (+)-(3S,4S)-7-hydroxy-Δ-6-tetrahydrocannabinol (HU-211), was found to be more active in inhibiting ADP-induced platelet aggregation than the highly psychotropic (-)-enantiomer (HU-210). The related (+)-(3R,4R) cannabinoid, HU-213, which lacks the 7-hydroxy moiety, exerted its inhibitory effect within a wider range of concentrations. The results indicate a differentiation between psychotropic activity and inhibition of platelet aggregation in the cannabinoid group of compounds.

Original languageEnglish
Pages (from-to)1305-1308
Number of pages4
JournalCanadian Journal of Physiology and Pharmacology
Volume70
Issue number10
DOIs
StatePublished - 1 Jan 1992

Keywords

  • enantiomeric cannabinoids
  • platelet aggregation

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