Effect of transmembrane pressure on rejection of viruses by ultrafiltration membranes

Elizabeth Arkhangelsky; Vitaly Gitis

doi:10.1016/j.seppur.2008.03.013

Effect of transmembrane pressure on rejection of viruses by ultrafiltration membranes

Elizabeth Arkhangelsky, Vitaly Gitis

Research output: Contribution to journal › Article › peer-review

68 Scopus citations

Abstract

Although partial penetration of ultrafiltration membranes by viruses and bacteria is well documented, there is no satisfactory explanation for the phenomenon. The current study seeks a possible explanation by studying the retention of viruses at different transmembrane pressures (TMPs). In contrast to previous predictions, higher TMPs lead to reduced virus retention levels. Based on indirect evidences it is proposed that the penetration occurs because of the formation during operation, rather than the initial presence, of abnormally large pores. It is therefore suggested that since pore enlargement is induced by high TMPs, high virus retention levels can be obtained only at low TMP values.

Original language	English
Pages (from-to)	619-628
Number of pages	10
Journal	Separation and Purification Technology
Volume	62
Issue number	3
DOIs	https://doi.org/10.1016/j.seppur.2008.03.013
State	Published - 22 Sep 2008

Keywords

E. coli
MS2
PES membrane
T4
phi X174

ASJC Scopus subject areas

Analytical Chemistry
Filtration and Separation

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10.1016/j.seppur.2008.03.013

Cite this

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title = "Effect of transmembrane pressure on rejection of viruses by ultrafiltration membranes",

abstract = "Although partial penetration of ultrafiltration membranes by viruses and bacteria is well documented, there is no satisfactory explanation for the phenomenon. The current study seeks a possible explanation by studying the retention of viruses at different transmembrane pressures (TMPs). In contrast to previous predictions, higher TMPs lead to reduced virus retention levels. Based on indirect evidences it is proposed that the penetration occurs because of the formation during operation, rather than the initial presence, of abnormally large pores. It is therefore suggested that since pore enlargement is induced by high TMPs, high virus retention levels can be obtained only at low TMP values.",

keywords = "E. coli, MS2, PES membrane, T4, phi X174",

author = "Elizabeth Arkhangelsky and Vitaly Gitis",

note = "Funding Information: This project was partially supported by a grant from The Stephen and Nancy Grand Water Research Institute (GWRI). E.A. thanks the Rieger Foundation for a Rieger-JNF fellowship in environmental studies. Special thanks are due to Mrs. I. Mureinik and Mr. P. Martin for scientific editing of the manuscript.",

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AU - Arkhangelsky, Elizabeth

AU - Gitis, Vitaly

N1 - Funding Information: This project was partially supported by a grant from The Stephen and Nancy Grand Water Research Institute (GWRI). E.A. thanks the Rieger Foundation for a Rieger-JNF fellowship in environmental studies. Special thanks are due to Mrs. I. Mureinik and Mr. P. Martin for scientific editing of the manuscript.

PY - 2008/9/22

Y1 - 2008/9/22

N2 - Although partial penetration of ultrafiltration membranes by viruses and bacteria is well documented, there is no satisfactory explanation for the phenomenon. The current study seeks a possible explanation by studying the retention of viruses at different transmembrane pressures (TMPs). In contrast to previous predictions, higher TMPs lead to reduced virus retention levels. Based on indirect evidences it is proposed that the penetration occurs because of the formation during operation, rather than the initial presence, of abnormally large pores. It is therefore suggested that since pore enlargement is induced by high TMPs, high virus retention levels can be obtained only at low TMP values.

AB - Although partial penetration of ultrafiltration membranes by viruses and bacteria is well documented, there is no satisfactory explanation for the phenomenon. The current study seeks a possible explanation by studying the retention of viruses at different transmembrane pressures (TMPs). In contrast to previous predictions, higher TMPs lead to reduced virus retention levels. Based on indirect evidences it is proposed that the penetration occurs because of the formation during operation, rather than the initial presence, of abnormally large pores. It is therefore suggested that since pore enlargement is induced by high TMPs, high virus retention levels can be obtained only at low TMP values.

KW - E. coli

KW - MS2

KW - PES membrane

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Effect of transmembrane pressure on rejection of viruses by ultrafiltration membranes

Abstract

Keywords

ASJC Scopus subject areas

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