Effect of uremic toxins - guanidino compounds and creatinine - on proliferation of HL60 and K562 cell lines

I. Nathan, R. Hensel, A. Dvilansky, R. Shainkin-Kestenbaum

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Growth of the promyelocytic cell line HL60 and the erythroleukemia cell line K562 is inhibited by 'uremic toxins': creatinine, guanidino propionic acid and guanidino succinic acid in a concentration range similar to that of uremic sera. Among the tested compounds, creatinine exhibits the strongest and most dose-dependent inhibitory effect on both kinds of cells. These results provide a better understanding of the mechanism involved in the anemia of uremic patients.

Original languageEnglish
Pages (from-to)251-252
Number of pages2
JournalNephron
Volume52
Issue number3
DOIs
StatePublished - 1 Jan 1989

ASJC Scopus subject areas

  • Physiology
  • Nephrology
  • Physiology (medical)
  • Urology

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