Abstract
Growth of the promyelocytic cell line HL60 and the erythroleukemia cell line K562 is inhibited by 'uremic toxins': creatinine, guanidino propionic acid and guanidino succinic acid in a concentration range similar to that of uremic sera. Among the tested compounds, creatinine exhibits the strongest and most dose-dependent inhibitory effect on both kinds of cells. These results provide a better understanding of the mechanism involved in the anemia of uremic patients.
Original language | English |
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Pages (from-to) | 251-252 |
Number of pages | 2 |
Journal | Nephron |
Volume | 52 |
Issue number | 3 |
DOIs | |
State | Published - 1 Jan 1989 |
ASJC Scopus subject areas
- Physiology
- Nephrology
- Physiology (medical)
- Urology