TY - JOUR
T1 - Effect of weight loss on blood pressure, arterial compliance, and insulin resistance in normotensive obese subjects
AU - Schneider, Rosa
AU - Golzman, Boris
AU - Turkot, Svetlana
AU - Kogan, Jacob
AU - Oren, Shmuel
PY - 2005/1/1
Y1 - 2005/1/1
N2 - Background: Obesity is characterized by insulin resistance and hyperinsulinemia that may elevate arterial pressure due to sympathetic overactivity and volume overload. The aim of the study is to measure hemodynamic parameters and metabolic variables in obese normotensive subjects. Methods: Twenty-four normotensive, overweight subjects from our medical staff were enrolled. They had personal and group meetings with a physician, dietician, and psychologist to improve their compliance with regard to physical activity and personal low-calorie diet. In addition, each subject was given orlistat 120 mg three times daily for 12 weeks. Noninvasive hemodynamic parameters including arterial compliance were measured using radial artery pulse wave analysis, at the beginning and 1 month after taking the last dose of Orlistat, and insulin resistance was calculated using HOMA score. Results: At the end of the 3-month period, the average weight was reduced from 89.5 ± 12 kg to 81.5 ± 9 kg. The systolic arterial pressure was reduced from 128 ± 12 mm Hg to 121 ± 10 mm Hg and diastolic arterial pressure was reduced from 75.4 ± 9 mm Hg to 69.6 ± 7 mm Hg. Arterial compliance measurements showed significant improvement in large artery compliance from 13 ± 4 to 15.8 ± 3.6 while no change occurred in small arteries. The insulin sensitivity assessed by HOMA score improved significantly from 6.5 ± 4.5 to 4.8 ± 3.1 with weight reduction. Conclusions: Our data show that weight loss is accompanied by lowering of blood pressure, even in normotensive obese patients. This weight loss brings about an improvement in insulin resistance and a rise in large artery compliance, whereas no change occurs in small artery compliance.
AB - Background: Obesity is characterized by insulin resistance and hyperinsulinemia that may elevate arterial pressure due to sympathetic overactivity and volume overload. The aim of the study is to measure hemodynamic parameters and metabolic variables in obese normotensive subjects. Methods: Twenty-four normotensive, overweight subjects from our medical staff were enrolled. They had personal and group meetings with a physician, dietician, and psychologist to improve their compliance with regard to physical activity and personal low-calorie diet. In addition, each subject was given orlistat 120 mg three times daily for 12 weeks. Noninvasive hemodynamic parameters including arterial compliance were measured using radial artery pulse wave analysis, at the beginning and 1 month after taking the last dose of Orlistat, and insulin resistance was calculated using HOMA score. Results: At the end of the 3-month period, the average weight was reduced from 89.5 ± 12 kg to 81.5 ± 9 kg. The systolic arterial pressure was reduced from 128 ± 12 mm Hg to 121 ± 10 mm Hg and diastolic arterial pressure was reduced from 75.4 ± 9 mm Hg to 69.6 ± 7 mm Hg. Arterial compliance measurements showed significant improvement in large artery compliance from 13 ± 4 to 15.8 ± 3.6 while no change occurred in small arteries. The insulin sensitivity assessed by HOMA score improved significantly from 6.5 ± 4.5 to 4.8 ± 3.1 with weight reduction. Conclusions: Our data show that weight loss is accompanied by lowering of blood pressure, even in normotensive obese patients. This weight loss brings about an improvement in insulin resistance and a rise in large artery compliance, whereas no change occurs in small artery compliance.
KW - Arterial compliance
KW - Hemodynamic parameters
KW - Insulin resistance
KW - Metabolic variables
KW - Normotensive
UR - http://www.scopus.com/inward/record.url?scp=27244455736&partnerID=8YFLogxK
U2 - 10.1097/00000441-200510000-00001
DO - 10.1097/00000441-200510000-00001
M3 - Article
C2 - 16234606
AN - SCOPUS:27244455736
SN - 0002-9629
VL - 330
SP - 157
EP - 160
JO - American Journal of the Medical Sciences
JF - American Journal of the Medical Sciences
IS - 4
ER -