Effective avoidance of a functional spect-perfused lung using intensity modulated radiotherapy (IMRT) for non-small cell lung cancer (NSCLC): An update of a planning study

Konstantin Lavrenkov; Shalini Singh; Judith A. Christian; Mike Partridge; Elena Nioutsikou; Gary Cook; James L. Bedford; Michael Brada

doi:10.1016/j.radonc.2008.10.005

Effective avoidance of a functional spect-perfused lung using intensity modulated radiotherapy (IMRT) for non-small cell lung cancer (NSCLC): An update of a planning study

Konstantin Lavrenkov, Shalini Singh, Judith A. Christian, Mike Partridge, Elena Nioutsikou, Gary Cook, James L. Bedford, Michael Brada

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

Abstract

IMRT and 3-dimensional conformal radiotherapy (3-DCRT) plans of 25 patients with non-small cell lung (NSCLC) were compared in terms of planning target volume (PTV) coverage and sparing of functional lung (FL) defined by a SPECT perfusion scan. IMRT resulted in significant reduction of functional V₂₀ and mean lung dose in stage III patients with inhomogeneous hypoperfusion. If the dose to FL is shown to be the determinant of lung toxicity, IMRT would allow for effective dose escalation by specific avoidance of functional lung.

Original language	English
Pages (from-to)	349-352
Number of pages	4
Journal	Radiotherapy and Oncology
Volume	91
Issue number	3
DOIs	https://doi.org/10.1016/j.radonc.2008.10.005
State	Published - 1 Jun 2009

Keywords

Functional imaging
Intensity modulated radiotherapy
Non-small cell lung cancer
Radiation pneumonitis
Radiotherapy treatment planning

ASJC Scopus subject areas

Hematology
Oncology
Radiology Nuclear Medicine and imaging

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.radonc.2008.10.005

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Lavrenkov, K., Singh, S., Christian, J. A., Partridge, M., Nioutsikou, E., Cook, G., Bedford, J. L., & Brada, M. (2009). Effective avoidance of a functional spect-perfused lung using intensity modulated radiotherapy (IMRT) for non-small cell lung cancer (NSCLC): An update of a planning study. Radiotherapy and Oncology, 91(3), 349-352. https://doi.org/10.1016/j.radonc.2008.10.005

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abstract = "IMRT and 3-dimensional conformal radiotherapy (3-DCRT) plans of 25 patients with non-small cell lung (NSCLC) were compared in terms of planning target volume (PTV) coverage and sparing of functional lung (FL) defined by a SPECT perfusion scan. IMRT resulted in significant reduction of functional V20 and mean lung dose in stage III patients with inhomogeneous hypoperfusion. If the dose to FL is shown to be the determinant of lung toxicity, IMRT would allow for effective dose escalation by specific avoidance of functional lung.",

keywords = "Functional imaging, Intensity modulated radiotherapy, Non-small cell lung cancer, Radiation pneumonitis, Radiotherapy treatment planning",

author = "Konstantin Lavrenkov and Shalini Singh and Christian, {Judith A.} and Mike Partridge and Elena Nioutsikou and Gary Cook and Bedford, {James L.} and Michael Brada",

note = "Funding Information: Dr. Lavrenkov was the recipient of the Barclays Family Cancer Research Foundation Fellowship, and Dr. J. Christian was funded by Cancer Research UK. The Academic Radiotherapy Unit received part of its funding from Cancer Research UK and The Royal Marsden NHS Foundation Trust. UK hospitals receive a proportion of their funding from the NHS Executive; the views expressed are those of the authors and not necessarily those of the NHS Executive.",

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Lavrenkov, K, Singh, S, Christian, JA, Partridge, M, Nioutsikou, E, Cook, G, Bedford, JL & Brada, M 2009, 'Effective avoidance of a functional spect-perfused lung using intensity modulated radiotherapy (IMRT) for non-small cell lung cancer (NSCLC): An update of a planning study', Radiotherapy and Oncology, vol. 91, no. 3, pp. 349-352. https://doi.org/10.1016/j.radonc.2008.10.005

Effective avoidance of a functional spect-perfused lung using intensity modulated radiotherapy (IMRT) for non-small cell lung cancer (NSCLC): An update of a planning study. / Lavrenkov, Konstantin; Singh, Shalini; Christian, Judith A. et al.
In: Radiotherapy and Oncology, Vol. 91, No. 3, 01.06.2009, p. 349-352.

Research output: Contribution to journal › Article › peer-review

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T2 - An update of a planning study

AU - Lavrenkov, Konstantin

AU - Singh, Shalini

AU - Christian, Judith A.

AU - Partridge, Mike

AU - Nioutsikou, Elena

AU - Cook, Gary

AU - Bedford, James L.

AU - Brada, Michael

N1 - Funding Information: Dr. Lavrenkov was the recipient of the Barclays Family Cancer Research Foundation Fellowship, and Dr. J. Christian was funded by Cancer Research UK. The Academic Radiotherapy Unit received part of its funding from Cancer Research UK and The Royal Marsden NHS Foundation Trust. UK hospitals receive a proportion of their funding from the NHS Executive; the views expressed are those of the authors and not necessarily those of the NHS Executive.

PY - 2009/6/1

Y1 - 2009/6/1

N2 - IMRT and 3-dimensional conformal radiotherapy (3-DCRT) plans of 25 patients with non-small cell lung (NSCLC) were compared in terms of planning target volume (PTV) coverage and sparing of functional lung (FL) defined by a SPECT perfusion scan. IMRT resulted in significant reduction of functional V20 and mean lung dose in stage III patients with inhomogeneous hypoperfusion. If the dose to FL is shown to be the determinant of lung toxicity, IMRT would allow for effective dose escalation by specific avoidance of functional lung.

AB - IMRT and 3-dimensional conformal radiotherapy (3-DCRT) plans of 25 patients with non-small cell lung (NSCLC) were compared in terms of planning target volume (PTV) coverage and sparing of functional lung (FL) defined by a SPECT perfusion scan. IMRT resulted in significant reduction of functional V20 and mean lung dose in stage III patients with inhomogeneous hypoperfusion. If the dose to FL is shown to be the determinant of lung toxicity, IMRT would allow for effective dose escalation by specific avoidance of functional lung.

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KW - Intensity modulated radiotherapy

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Effective avoidance of a functional spect-perfused lung using intensity modulated radiotherapy (IMRT) for non-small cell lung cancer (NSCLC): An update of a planning study

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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