Effective avoidance of a functional spect-perfused lung using intensity modulated radiotherapy (IMRT) for non-small cell lung cancer (NSCLC): An update of a planning study

Konstantin Lavrenkov; Shalini Singh; Judith A. Christian; Mike Partridge; Elena Nioutsikou; Gary Cook; James L. Bedford; Michael Brada

doi:10.1016/j.radonc.2008.10.005

Effective avoidance of a functional spect-perfused lung using intensity modulated radiotherapy (IMRT) for non-small cell lung cancer (NSCLC): An update of a planning study

Konstantin Lavrenkov
, Shalini Singh
, Judith A. Christian
, Mike Partridge
, Elena Nioutsikou
, Gary Cook
, James L. Bedford
, Michael Brada

Internal Medicine Division

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

Abstract

IMRT and 3-dimensional conformal radiotherapy (3-DCRT) plans of 25 patients with non-small cell lung (NSCLC) were compared in terms of planning target volume (PTV) coverage and sparing of functional lung (FL) defined by a SPECT perfusion scan. IMRT resulted in significant reduction of functional V₂₀ and mean lung dose in stage III patients with inhomogeneous hypoperfusion. If the dose to FL is shown to be the determinant of lung toxicity, IMRT would allow for effective dose escalation by specific avoidance of functional lung.

Original language	English
Pages (from-to)	349-352
Number of pages	4
Journal	Radiotherapy and Oncology
Volume	91
Issue number	3
DOIs	https://doi.org/10.1016/j.radonc.2008.10.005
State	Published - 1 Jun 2009

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Functional imaging
Intensity modulated radiotherapy
Non-small cell lung cancer
Radiation pneumonitis
Radiotherapy treatment planning

ASJC Scopus subject areas

Hematology
Oncology
Radiology Nuclear Medicine and imaging

Access to Document

10.1016/j.radonc.2008.10.005

Cite this

Lavrenkov, K., Singh, S., Christian, J. A., Partridge, M., Nioutsikou, E., Cook, G., Bedford, J. L., & Brada, M. (2009). Effective avoidance of a functional spect-perfused lung using intensity modulated radiotherapy (IMRT) for non-small cell lung cancer (NSCLC): An update of a planning study. Radiotherapy and Oncology, 91(3), 349-352. https://doi.org/10.1016/j.radonc.2008.10.005

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title = "Effective avoidance of a functional spect-perfused lung using intensity modulated radiotherapy (IMRT) for non-small cell lung cancer (NSCLC): An update of a planning study",

abstract = "IMRT and 3-dimensional conformal radiotherapy (3-DCRT) plans of 25 patients with non-small cell lung (NSCLC) were compared in terms of planning target volume (PTV) coverage and sparing of functional lung (FL) defined by a SPECT perfusion scan. IMRT resulted in significant reduction of functional V20 and mean lung dose in stage III patients with inhomogeneous hypoperfusion. If the dose to FL is shown to be the determinant of lung toxicity, IMRT would allow for effective dose escalation by specific avoidance of functional lung.",

keywords = "Functional imaging, Intensity modulated radiotherapy, Non-small cell lung cancer, Radiation pneumonitis, Radiotherapy treatment planning",

author = "Konstantin Lavrenkov and Shalini Singh and Christian, \{Judith A.\} and Mike Partridge and Elena Nioutsikou and Gary Cook and Bedford, \{James L.\} and Michael Brada",

year = "2009",

month = jun,

day = "1",

doi = "10.1016/j.radonc.2008.10.005",

language = "English",

volume = "91",

pages = "349--352",

journal = "Radiotherapy and Oncology",

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Lavrenkov, K, Singh, S, Christian, JA, Partridge, M, Nioutsikou, E, Cook, G, Bedford, JL & Brada, M 2009, 'Effective avoidance of a functional spect-perfused lung using intensity modulated radiotherapy (IMRT) for non-small cell lung cancer (NSCLC): An update of a planning study', Radiotherapy and Oncology, vol. 91, no. 3, pp. 349-352. https://doi.org/10.1016/j.radonc.2008.10.005

Effective avoidance of a functional spect-perfused lung using intensity modulated radiotherapy (IMRT) for non-small cell lung cancer (NSCLC): An update of a planning study. / Lavrenkov, Konstantin; Singh, Shalini; Christian, Judith A. et al.
In: Radiotherapy and Oncology, Vol. 91, No. 3, 01.06.2009, p. 349-352.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Effective avoidance of a functional spect-perfused lung using intensity modulated radiotherapy (IMRT) for non-small cell lung cancer (NSCLC)

T2 - An update of a planning study

AU - Lavrenkov, Konstantin

AU - Singh, Shalini

AU - Christian, Judith A.

AU - Partridge, Mike

AU - Nioutsikou, Elena

AU - Cook, Gary

AU - Bedford, James L.

AU - Brada, Michael

PY - 2009/6/1

Y1 - 2009/6/1

N2 - IMRT and 3-dimensional conformal radiotherapy (3-DCRT) plans of 25 patients with non-small cell lung (NSCLC) were compared in terms of planning target volume (PTV) coverage and sparing of functional lung (FL) defined by a SPECT perfusion scan. IMRT resulted in significant reduction of functional V20 and mean lung dose in stage III patients with inhomogeneous hypoperfusion. If the dose to FL is shown to be the determinant of lung toxicity, IMRT would allow for effective dose escalation by specific avoidance of functional lung.

AB - IMRT and 3-dimensional conformal radiotherapy (3-DCRT) plans of 25 patients with non-small cell lung (NSCLC) were compared in terms of planning target volume (PTV) coverage and sparing of functional lung (FL) defined by a SPECT perfusion scan. IMRT resulted in significant reduction of functional V20 and mean lung dose in stage III patients with inhomogeneous hypoperfusion. If the dose to FL is shown to be the determinant of lung toxicity, IMRT would allow for effective dose escalation by specific avoidance of functional lung.

KW - Functional imaging

KW - Intensity modulated radiotherapy

KW - Non-small cell lung cancer

KW - Radiation pneumonitis

KW - Radiotherapy treatment planning

UR - https://www.scopus.com/pages/publications/65749088930

U2 - 10.1016/j.radonc.2008.10.005

DO - 10.1016/j.radonc.2008.10.005

M3 - Article

C2 - 18995919

AN - SCOPUS:65749088930

SN - 0167-8140

VL - 91

SP - 349

EP - 352

JO - Radiotherapy and Oncology

JF - Radiotherapy and Oncology

IS - 3

ER -

Effective avoidance of a functional spect-perfused lung using intensity modulated radiotherapy (IMRT) for non-small cell lung cancer (NSCLC): An update of a planning study

Abstract

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

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