TY - JOUR
T1 - Effectiveness of the BNT162b2 mRNA COVID-19 vaccine in pregnancy
AU - Dagan, Noa
AU - Barda, Noam
AU - Biron-Shental, Tal
AU - Makov-Assif, Maya
AU - Key, Calanit
AU - Kohane, Isaac S.
AU - Hernán, Miguel A.
AU - Lipsitch, Marc
AU - Hernandez-Diaz, Sonia
AU - Reis, Ben Y.
AU - Balicer, Ran D.
N1 - Publisher Copyright:
© 2021, The Author(s), under exclusive licence to Springer Nature America, Inc.
PY - 2021/10/1
Y1 - 2021/10/1
N2 - To evaluate the effectiveness of the BNT162b2 messenger RNA vaccine in pregnant women, we conducted an observational cohort study of pregnant women aged 16 years or older, with no history of SARS-CoV-2, who were vaccinated between 20 December 2020 and 3 June 2021. A total of 10,861 vaccinated pregnant women were matched to 10,861 unvaccinated pregnant controls using demographic and clinical characteristics. Study outcomes included documented infection with SARS-CoV-2, symptomatic COVID-19, COVID-19-related hospitalization, severe illness and death. Estimated vaccine effectiveness from 7 through to 56 d after the second dose was 96% (95% confidence interval 89–100%) for any documented infection, 97% (91–100%) for infections with documented symptoms and 89% (43–100%) for COVID-19-related hospitalization. Only one event of severe illness was observed in the unvaccinated group and no deaths were observed in either group. In summary, the BNT162b2 mRNA vaccine was estimated to have high vaccine effectiveness in pregnant women, which is similar to the effectiveness estimated in the general population.
AB - To evaluate the effectiveness of the BNT162b2 messenger RNA vaccine in pregnant women, we conducted an observational cohort study of pregnant women aged 16 years or older, with no history of SARS-CoV-2, who were vaccinated between 20 December 2020 and 3 June 2021. A total of 10,861 vaccinated pregnant women were matched to 10,861 unvaccinated pregnant controls using demographic and clinical characteristics. Study outcomes included documented infection with SARS-CoV-2, symptomatic COVID-19, COVID-19-related hospitalization, severe illness and death. Estimated vaccine effectiveness from 7 through to 56 d after the second dose was 96% (95% confidence interval 89–100%) for any documented infection, 97% (91–100%) for infections with documented symptoms and 89% (43–100%) for COVID-19-related hospitalization. Only one event of severe illness was observed in the unvaccinated group and no deaths were observed in either group. In summary, the BNT162b2 mRNA vaccine was estimated to have high vaccine effectiveness in pregnant women, which is similar to the effectiveness estimated in the general population.
UR - http://www.scopus.com/inward/record.url?scp=85114643001&partnerID=8YFLogxK
U2 - 10.1038/s41591-021-01490-8
DO - 10.1038/s41591-021-01490-8
M3 - Article
C2 - 34493859
AN - SCOPUS:85114643001
SN - 1078-8956
VL - 27
SP - 1693
EP - 1695
JO - Nature Medicine
JF - Nature Medicine
IS - 10
ER -