Effects of acetyl-L-carnitine and myo-inositol on high-energy phosphate and membrane phospholipid metabolism in zebra fish: A 31P-NMR-spectroscopy study

J. Levine; K. Panchalingam; R. J. McClure; S. Gershon; J. W. Pettegrew

doi:10.1023/A:1022849430947

Effects of acetyl-L-carnitine and myo-inositol on high-energy phosphate and membrane phospholipid metabolism in zebra fish: A ³¹P-NMR-spectroscopy study

J. Levine
, K. Panchalingam
, R. J. McClure
, S. Gershon
, J. W. Pettegrew

Psychiatry Division

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Acetyl-L-carnitine (ALCAR) and myo-inositol are reported to enhance motor activity in animal models; modulate membrane phospholipid metabolism (ALCAR and myo-inositol) and highenergy phosphate metabolism (ALCAR) back to normal; and be effective treatments of major depression in humans. Fish in general and zebra fish in particular present unique animal models for the in vivo study of high-energy phosphate and membrane phospholipid metabolism by noninvasive in vivo ³¹P NMR. This ³¹P NMR study of free-swimming zebra fish showed that both ALCAR and myo-inositol decreased levels of phosphodiesters and inorganic orthophosphate and increased levels of PCr in the fish. These findings demonstrate both ALCAR and myo-inositol modulate membrane phospholipid and high-energy phosphate metabolism in freeswimming zebra fish.

Original language	English
Pages (from-to)	687-690
Number of pages	4
Journal	Neurochemical Research
Volume	28
Issue number	5
DOIs	https://doi.org/10.1023/A:1022849430947
State	Published - 1 May 2003

Keywords

Acetyl-L-carnitine
High-energy phosphate metabolism
Membrane phospholipid metabolism
Myo-inositol
P NMR
Zebra fish

ASJC Scopus subject areas

Biochemistry
Cellular and Molecular Neuroscience

Access to Document

10.1023/A:1022849430947

Cite this

@article{5bc0b10dc67c491c9c99536614c018ba,

title = "Effects of acetyl-L-carnitine and myo-inositol on high-energy phosphate and membrane phospholipid metabolism in zebra fish: A 31P-NMR-spectroscopy study",

abstract = "Acetyl-L-carnitine (ALCAR) and myo-inositol are reported to enhance motor activity in animal models; modulate membrane phospholipid metabolism (ALCAR and myo-inositol) and highenergy phosphate metabolism (ALCAR) back to normal; and be effective treatments of major depression in humans. Fish in general and zebra fish in particular present unique animal models for the in vivo study of high-energy phosphate and membrane phospholipid metabolism by noninvasive in vivo 31P NMR. This 31P NMR study of free-swimming zebra fish showed that both ALCAR and myo-inositol decreased levels of phosphodiesters and inorganic orthophosphate and increased levels of PCr in the fish. These findings demonstrate both ALCAR and myo-inositol modulate membrane phospholipid and high-energy phosphate metabolism in freeswimming zebra fish.",

keywords = "Acetyl-L-carnitine, High-energy phosphate metabolism, Membrane phospholipid metabolism, Myo-inositol, P NMR, Zebra fish",

author = "J. Levine and K. Panchalingam and McClure, \{R. J.\} and S. Gershon and Pettegrew, \{J. W.\}",

year = "2003",

month = may,

day = "1",

doi = "10.1023/A:1022849430947",

language = "English",

volume = "28",

pages = "687--690",

journal = "Neurochemical Research",

issn = "0364-3190",

publisher = "Springer",

number = "5",

}

TY - JOUR

T1 - Effects of acetyl-L-carnitine and myo-inositol on high-energy phosphate and membrane phospholipid metabolism in zebra fish

T2 - A 31P-NMR-spectroscopy study

AU - Levine, J.

AU - Panchalingam, K.

AU - McClure, R. J.

AU - Gershon, S.

AU - Pettegrew, J. W.

PY - 2003/5/1

Y1 - 2003/5/1

N2 - Acetyl-L-carnitine (ALCAR) and myo-inositol are reported to enhance motor activity in animal models; modulate membrane phospholipid metabolism (ALCAR and myo-inositol) and highenergy phosphate metabolism (ALCAR) back to normal; and be effective treatments of major depression in humans. Fish in general and zebra fish in particular present unique animal models for the in vivo study of high-energy phosphate and membrane phospholipid metabolism by noninvasive in vivo 31P NMR. This 31P NMR study of free-swimming zebra fish showed that both ALCAR and myo-inositol decreased levels of phosphodiesters and inorganic orthophosphate and increased levels of PCr in the fish. These findings demonstrate both ALCAR and myo-inositol modulate membrane phospholipid and high-energy phosphate metabolism in freeswimming zebra fish.

AB - Acetyl-L-carnitine (ALCAR) and myo-inositol are reported to enhance motor activity in animal models; modulate membrane phospholipid metabolism (ALCAR and myo-inositol) and highenergy phosphate metabolism (ALCAR) back to normal; and be effective treatments of major depression in humans. Fish in general and zebra fish in particular present unique animal models for the in vivo study of high-energy phosphate and membrane phospholipid metabolism by noninvasive in vivo 31P NMR. This 31P NMR study of free-swimming zebra fish showed that both ALCAR and myo-inositol decreased levels of phosphodiesters and inorganic orthophosphate and increased levels of PCr in the fish. These findings demonstrate both ALCAR and myo-inositol modulate membrane phospholipid and high-energy phosphate metabolism in freeswimming zebra fish.

KW - Acetyl-L-carnitine

KW - High-energy phosphate metabolism

KW - Membrane phospholipid metabolism

KW - Myo-inositol

KW - P NMR

KW - Zebra fish

UR - https://www.scopus.com/pages/publications/0037403831

U2 - 10.1023/A:1022849430947

DO - 10.1023/A:1022849430947

M3 - Article

C2 - 12716017

AN - SCOPUS:0037403831

SN - 0364-3190

VL - 28

SP - 687

EP - 690

JO - Neurochemical Research

JF - Neurochemical Research

IS - 5

ER -