Effects of adrenoceptor agonists and antagonists on sulfobromophthalein disposition in mice

Zvi Ben-Zvi, Aryeh Hurwitz

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


The effects of α2-adrenoceptor agonists on sulfobromophthalein (BSP) disposition in mice were studied. It was found that agents with both central and peripheral activities (clonidine, guanabenz, B-HT 920 and methyldopa) as well as peripherally acting α2-adrenoceptor agonists (para amino-clonidine and St 91) inhibited sulfobromophthalein disposition in the mouse, and also caused substantial hypothermia. The effects of these agonists were inhibited by yohimbine, a specific α2-antagonist, except for those of para amino-clonidine where only partial reversal was achieved. The effects of clonidine on BSP disposition were also reversed by piperoxan but not by the α1-adrenoceptor antagonists, prazosin and phenoxybenzamine, nor by the β-blocker, propranolol. These results suggest that, in mice, peripheral α2-adrenoceptors are involved in the effects of the α-agonists on BSP disposition.

Original languageEnglish
Pages (from-to)191-196
Number of pages6
JournalEuropean Journal of Pharmacology
Issue number2-3
StatePublished - 4 Jun 1987


  • Clonidine
  • Hypothermia
  • Sulfobromophthalein
  • α-Adrenoceptor agonists
  • α-Adrenoceptor antagonists

ASJC Scopus subject areas

  • Pharmacology


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