Effects of aqueous extract of Notobasis syriaca on lipopolysaccharide-induced inflammation in rats

Abdullatif Azab, Ahmad Nassar, Jacob Kaplanski, Reem Mahajneh, Galila Agam, Abed N. Azab

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations

Abstract

Objective: To investigate the effects of a dry aqueous extract of Notobasis syriaca (N. syriaca) on lipopolysaccharide (LPS)-induced inflammation in rats. Methods: Rats were fed the dried extract [500 mg/(kg•d)] for three consecutive days and then were intraperitoneally injected with LPS (1 mg/kg). Two hours after LPS injection, rats were sacrificed and blood and brain regions were collected. Inflammatory mediators' levels in plasma and homogenates of brain regions were determined by ELISA. Results: Pretreatment with the N. syriaca extract resulted in significant anti-inflammatory effects (P<0.05), including: i) attenuated LPS-induced hypothermia; ii) decreased hypothalamus and hippocampus prostaglandin E2 levels in the LPStreated rats; and, iii) reduced hypothalamus and hippocampus interleukin-6 and tumor necrosis factor-毩levels in the LPS-treated rats. Conclusions: These results suggest that N. syriaca possesses anti-inflammatory properties. Thus, it is possible that long-term consumption of this plant may result in beneficial pharmacological effects.

Original languageEnglish
Pages (from-to)48-52
Number of pages5
JournalAsian Pacific Journal of Tropical Medicine
Volume11
Issue number1
DOIs
StatePublished - 1 Jan 2018

Keywords

  • Bacterial endotoxin
  • Brain
  • Cytokines
  • Hypothermia
  • Natural products
  • Plants

ASJC Scopus subject areas

  • Medicine (all)

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