Effects of dose and interdose interval on locomotor sensitization to the dopamine agonist quinpirole

Henry Szechtman, Hugh Dai, Shahzad Mustafa, Haim Einat, Ron M. Sullivan

Research output: Contribution to journalArticlepeer-review

75 Scopus citations

Abstract

To assess whether the interval between injections affects the course of locomotor sensitization to quinpirole, groups of rats were injected every 2, 4, or 8 days with quinpirole (0, 0.025, 0.25, 0.5, and 2.5 mg/kg; n = 222) and their locomotor activity monitored after each injection for a total of 10 tests. Results indicate that the number of drug injections, rather than the interval between them, predominantly controls the development of locomotor sensitization to quinpirole. It is suggested that this may reflect a rapid induction but slow decay time for a response-enhancing factor stimulated by each injection of quinpirole, and that the effects of this putative factor are cumulative but saturable.

Original languageEnglish
Pages (from-to)921-928
Number of pages8
JournalPharmacology Biochemistry and Behavior
Volume48
Issue number4
DOIs
StatePublished - 1 Jan 1994
Externally publishedYes

Keywords

  • Hyperactivity
  • Locomotion
  • Rats
  • Reverse tolerance
  • Time course of sensitization

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

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