TY - JOUR
T1 - Effects of dose and interdose interval on locomotor sensitization to the dopamine agonist quinpirole
AU - Szechtman, Henry
AU - Dai, Hugh
AU - Mustafa, Shahzad
AU - Einat, Haim
AU - Sullivan, Ron M.
N1 - Funding Information:
This work was supported by funds from the Medical Research Council of Canada (MT8905). H.S. is a Research Associate of the Ontario Mental Health Foundation. We thank Dr. A. K. (;rover for invaluable suggestions and comments and Mr. Faisal Ibrahim for performing a pilot experiment.
PY - 1994/1/1
Y1 - 1994/1/1
N2 - To assess whether the interval between injections affects the course of locomotor sensitization to quinpirole, groups of rats were injected every 2, 4, or 8 days with quinpirole (0, 0.025, 0.25, 0.5, and 2.5 mg/kg; n = 222) and their locomotor activity monitored after each injection for a total of 10 tests. Results indicate that the number of drug injections, rather than the interval between them, predominantly controls the development of locomotor sensitization to quinpirole. It is suggested that this may reflect a rapid induction but slow decay time for a response-enhancing factor stimulated by each injection of quinpirole, and that the effects of this putative factor are cumulative but saturable.
AB - To assess whether the interval between injections affects the course of locomotor sensitization to quinpirole, groups of rats were injected every 2, 4, or 8 days with quinpirole (0, 0.025, 0.25, 0.5, and 2.5 mg/kg; n = 222) and their locomotor activity monitored after each injection for a total of 10 tests. Results indicate that the number of drug injections, rather than the interval between them, predominantly controls the development of locomotor sensitization to quinpirole. It is suggested that this may reflect a rapid induction but slow decay time for a response-enhancing factor stimulated by each injection of quinpirole, and that the effects of this putative factor are cumulative but saturable.
KW - Hyperactivity
KW - Locomotion
KW - Rats
KW - Reverse tolerance
KW - Time course of sensitization
UR - http://www.scopus.com/inward/record.url?scp=0028043115&partnerID=8YFLogxK
U2 - 10.1016/0091-3057(94)90201-1
DO - 10.1016/0091-3057(94)90201-1
M3 - Article
C2 - 7972297
AN - SCOPUS:0028043115
SN - 0091-3057
VL - 48
SP - 921
EP - 928
JO - Pharmacology Biochemistry and Behavior
JF - Pharmacology Biochemistry and Behavior
IS - 4
ER -