Effects of indomethacin on hematopoiesis in mice

E. Razin, Y. Hayari, A. Globerson

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

The effect of indomethacin treatment on hematopoiesis in mice was examined. Twenty-four hours following the onset of treatment there was 3-fold increase in bone marrow non-specific esterase positive cells (NEPC) as compared to the initial level. Two days later a two-fold increase in spleen and peritoneal NEPC was observed.In all the organs examined, NEPC returned to its basal level after cessation of treatment. The increase in number of NEPC was accompanied by an elevation in CSF production. The effect of indomethacin on peripheral blood cells was also determined. A significant decrease in hematocrit level was found following the treatment. In addition, it was further found that following the drug treatment there was a significant reduction of erythrocyte number and hemoglobin levels.

Original languageEnglish
Pages (from-to)613-620
Number of pages8
JournalProstaglandins Leukotrienes and Essential Fatty Acids
Volume6
Issue number6
DOIs
StatePublished - 1 Jan 1981
Externally publishedYes

Keywords

  • CM, conditioned medium
  • CSF, colonies stimulating factor
  • NEPC, non-specific esterase positive cells
  • PG, prostaglandin

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