TY - JOUR
T1 - Effects of initiating moderate wine intake on abdominal adipose tissue in adults with type 2 diabetes
T2 - A 2-year randomized controlled trial
AU - Golan, Rachel
AU - Shelef, Ilan
AU - Shemesh, Elad
AU - Henkin, Yaakov
AU - Schwarzfuchs, Dan
AU - Gepner, Yftach
AU - Harman-Boehm, Ilana
AU - Witkow, Shula
AU - Friger, Michael
AU - Chassidim, Yoash
AU - Liberty, Idit F.
AU - Sarusi, Benjamin
AU - Serfaty, Dana
AU - Bril, Nitzan
AU - Rein, Michal
AU - Cohen, Noa
AU - Ben-Avraham, Sivan
AU - Ceglarek, Uta
AU - Stumvoll, Michael
AU - Blüher, Matthias
AU - Thiery, Joachim
AU - Stampfer, Meir J.
AU - Rudich, Assaf
AU - Shai, Iris
N1 - Publisher Copyright:
© The Authors 2016.
PY - 2017/2/1
Y1 - 2017/2/1
N2 - Objective To generate evidence-based conclusions about the effect of wine consumption on weight gain and abdominal fat accumulation and distribution in patients with type 2 diabetes. Design In the 2-year randomized controlled CASCADE (CArdiovaSCulAr Diabetes & Ethanol) trial, patients following a Mediterranean diet were randomly assigned to drink 150 ml of mineral water, white wine or red wine with dinner for 2 years. Visceral adiposity and abdominal fat distribution were measured in a subgroup of sixty-five participants, using abdominal MRI. Setting Ben-Gurion University of the Negev, Soroka-Medical Center and the Nuclear Research Center Negev, Israel. Subjects Alcohol-abstaining adults with well-controlled type 2 diabetes. Results Forty-eight participants (red wine, n 27; mineral water, n 21) who completed a second MRI measurement were included in the 2-year analysis. Similar weight losses (sd) were observed: red wine 1·3 (3·9) kg; water 1·0 (4·2) kg (P=0·8 between groups). Changes (95 % CI) in abdominal adipose-tissue distribution were similar: red wine, visceral adipose tissue (VAT) -3·0 (-8·0, 2·0) %, deep subcutaneous adipose tissue (DSAT) +5·2 (-1·1, 11·6) %, superficial subcutaneous adipose tissue (SSAT) -1·9 (-5·0, 1·2) %; water, VAT -3·2 (-8·9, 2·5) %, DSAT +2·9 (-2·8, 8·6) %, SSAT -0·15 (-3·3, 2·9) %. No changes in antidiabetic medication and no substantial changes in energy intake (+126 (sd 2889) kJ/d (+30·2 (sd 690) kcal/d), P=0·8) were recorded. A 2-year decrease in glycated Hb (β=0·28, P=0·05) was associated with a decrease in VAT. Conclusions Moderate wine consumption, as part of a Mediterranean diet, in persons with controlled diabetes did not promote weight gain or abdominal adiposity.
AB - Objective To generate evidence-based conclusions about the effect of wine consumption on weight gain and abdominal fat accumulation and distribution in patients with type 2 diabetes. Design In the 2-year randomized controlled CASCADE (CArdiovaSCulAr Diabetes & Ethanol) trial, patients following a Mediterranean diet were randomly assigned to drink 150 ml of mineral water, white wine or red wine with dinner for 2 years. Visceral adiposity and abdominal fat distribution were measured in a subgroup of sixty-five participants, using abdominal MRI. Setting Ben-Gurion University of the Negev, Soroka-Medical Center and the Nuclear Research Center Negev, Israel. Subjects Alcohol-abstaining adults with well-controlled type 2 diabetes. Results Forty-eight participants (red wine, n 27; mineral water, n 21) who completed a second MRI measurement were included in the 2-year analysis. Similar weight losses (sd) were observed: red wine 1·3 (3·9) kg; water 1·0 (4·2) kg (P=0·8 between groups). Changes (95 % CI) in abdominal adipose-tissue distribution were similar: red wine, visceral adipose tissue (VAT) -3·0 (-8·0, 2·0) %, deep subcutaneous adipose tissue (DSAT) +5·2 (-1·1, 11·6) %, superficial subcutaneous adipose tissue (SSAT) -1·9 (-5·0, 1·2) %; water, VAT -3·2 (-8·9, 2·5) %, DSAT +2·9 (-2·8, 8·6) %, SSAT -0·15 (-3·3, 2·9) %. No changes in antidiabetic medication and no substantial changes in energy intake (+126 (sd 2889) kJ/d (+30·2 (sd 690) kcal/d), P=0·8) were recorded. A 2-year decrease in glycated Hb (β=0·28, P=0·05) was associated with a decrease in VAT. Conclusions Moderate wine consumption, as part of a Mediterranean diet, in persons with controlled diabetes did not promote weight gain or abdominal adiposity.
KW - Abdominal adipose tissue
KW - MRI
KW - Mediterranean diet
KW - Type 2 diabetes
KW - Wine
UR - http://www.scopus.com/inward/record.url?scp=84989856968&partnerID=8YFLogxK
U2 - 10.1017/S1368980016002597
DO - 10.1017/S1368980016002597
M3 - Article
C2 - 27692023
AN - SCOPUS:84989856968
SN - 1368-9800
VL - 20
SP - 549
EP - 555
JO - Public Health Nutrition
JF - Public Health Nutrition
IS - 3
ER -
