TY - JOUR
T1 - Effects of Isoflavone-Rich NADES Extract of Pueraria lobata Roots and Astaxanthin-Rich Phaffia rhodozyma Extract on Prostate Carcinogenesis in Rats
AU - Semenov, Alexander L.
AU - Tyndyk, Margarita L.
AU - Von, Julia D.
AU - Ermakova, Elena D.
AU - Dorofeeva, Anastasia A.
AU - Tumanyan, Irina A.
AU - Radetskaya, Ekaterina A.
AU - Yurova, Maria N.
AU - Zherebker, Alexander
AU - Gorbunov, Alexander Yu
AU - Fedoros, Elena I.
AU - Panchenko, Andrey V.
AU - Anisimov, Vladimir N.
N1 - Publisher Copyright:
© 2023 by the authors.
PY - 2023/2/1
Y1 - 2023/2/1
N2 - Prostate cancer (PCa) is one of the most common male malignancies worldwide. In the current study, we evaluated the effects of a natural deep eutectic solvent (NADES) extract of Pueraria lobata roots rich in isoflavones (ISF) and Phaffia rhodozyma extract rich in astaxanthin (ASX) on an N-methyl-N-nitrosourea plus testosterone PCa model in rats. ISF consisted of puerarin, daidzein, genistein, formononetin and other polyphenols, while ASX contained lipids and unsaturated species in addition to astaxanthin. Extracts were administered through a whole promotion period in daily doses shown by our group to successfully inhibit benign prostate hyperplasia (BPH) development — 200 mg/kg for ISF and 25 mg/kg for ASX. Though a similar effect was found for BPH processes accompanying PCa induction, the incidence of PCa in animals treated with placebo, ISF and ASX was 37%, 37% and 41%, respectively, showing no chemopreventive activity of ISF and ASX. PCa development was associated with a decrease in the Ca/Mg ratio in serum and an increase in prostate tissue. Treatment with both extracts produced a normalization effect on Ca balance in serum, which, combined with a decrease in the prostatic index, suggests some positive health effects of ISF and ASX.
AB - Prostate cancer (PCa) is one of the most common male malignancies worldwide. In the current study, we evaluated the effects of a natural deep eutectic solvent (NADES) extract of Pueraria lobata roots rich in isoflavones (ISF) and Phaffia rhodozyma extract rich in astaxanthin (ASX) on an N-methyl-N-nitrosourea plus testosterone PCa model in rats. ISF consisted of puerarin, daidzein, genistein, formononetin and other polyphenols, while ASX contained lipids and unsaturated species in addition to astaxanthin. Extracts were administered through a whole promotion period in daily doses shown by our group to successfully inhibit benign prostate hyperplasia (BPH) development — 200 mg/kg for ISF and 25 mg/kg for ASX. Though a similar effect was found for BPH processes accompanying PCa induction, the incidence of PCa in animals treated with placebo, ISF and ASX was 37%, 37% and 41%, respectively, showing no chemopreventive activity of ISF and ASX. PCa development was associated with a decrease in the Ca/Mg ratio in serum and an increase in prostate tissue. Treatment with both extracts produced a normalization effect on Ca balance in serum, which, combined with a decrease in the prostatic index, suggests some positive health effects of ISF and ASX.
KW - FTICR-MS
KW - MNU
KW - NADES
KW - Phaffia rhodozyma
KW - Pueraria lobata
KW - astaxanthin
KW - calcium
KW - isoflavones
KW - magnesium
KW - oxidative stress
KW - prostate cancer
KW - rats
KW - testosterone
UR - https://www.scopus.com/pages/publications/85147824581
U2 - 10.3390/plants12030564
DO - 10.3390/plants12030564
M3 - Article
C2 - 36771648
AN - SCOPUS:85147824581
SN - 2223-7747
VL - 12
JO - Plants
JF - Plants
IS - 3
M1 - 564
ER -
