Effects of lesion extent and location on upper limb spasticity following hemispheric stroke

S Frenkel-Toledo, DG Liebermann, MF Levin, M Baniña, JM Solomon, S Berman, M Meimoun, N Soroker

Research output: Chapter in Book/Report/Conference proceedingConference contribution


Spasticity of the hemiparetic upper limb (UL) leading to difficulty performing activities of daily living is a major concern in stroke rehabilitation. Spasticity results from impaired control of motoneuronal activation thresholds exerted by descending direct and indirect pathways. This is reflected by pathological alteration of the specific muscle length/joint angle at which the stretch reflex and other proprioceptive reflexes begin to act (tonic stretch reflex threshold, TSRT). The relationship between lesion location and the appearance of spasticity is poorly understood. We investigated the relationship between lesion characteristics and elbow-flexor (biceps) TSRT in the hemiparetic UL, as part of an international multicenter RCT (ENHANCE project; ClinicalTrials.gov, ID: NCT02725853).
Original languageEnglish GB
Title of host publicationAnnals of Physical and Rehabilitation Medicine
Subtitle of host publication12th World Congress of the International Society of Physical and Rehabilitation Medicine. Paris. 8-12 July 2018
PublisherElsevier Masson
EditionSpecial issue
StatePublished - 2018


Dive into the research topics of 'Effects of lesion extent and location on upper limb spasticity following hemispheric stroke'. Together they form a unique fingerprint.

Cite this