Effects of lipopolysaccharide on body temperature and plasma zinc and iron concentrations in rats exposed to different ambient temperatures

J. Kaplanski, A. Magazanik, I. Hadas, U. Sod-Moriah, V. Fraifeld

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Lipopolysaccharide (LPS) induced biphasic changes in body temperature (T(b)) (initial hypothermia followed by hyperthermia) in male Sprague-Dawley rats kept at 22°C, and monophasic elevation in T(b) at 34°C. LPS decreased plasma zinc (Zn) or iron (Fe) concentrations, independently of heat-induced hyperthermia or LPS-induced changes in T(b). Acute or chronic exposure of rats to high ambient temperature modifies their T(b) response to LPS, but not the effects of LPS on plasma Zn and Fe concentrations. It appears that the reduction of these elements in plasma could represent a common response to stress, including the response to endotoxin.

Original languageEnglish
Pages (from-to)35-38
Number of pages4
JournalJournal of Thermal Biology
Volume25
Issue number1-2
DOIs
StatePublished - 1 Feb 2000

Keywords

  • Acute and chronic exposure to high ambient temperature
  • Acute phase responses
  • Body temperature
  • Fever
  • Heat-induced hyperthermia
  • Lipopolysaccharide
  • Plasma zinc and iron
  • Rats

Fingerprint

Dive into the research topics of 'Effects of lipopolysaccharide on body temperature and plasma zinc and iron concentrations in rats exposed to different ambient temperatures'. Together they form a unique fingerprint.

Cite this