Effects of lithium in vitro on noradrenaline-induced cyclic AMP accumulation in rat cortical slices after reserpine-induced supersensitivity

M. E. Newman, P. Lichtenberg, R. H. Belmaker

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Lithium in vitro at concentrations of 1-2 mM and above inhibited cyclic AMP accumulation due to noradrenaline in cerebral cortical slices prepared from both control rats and rats rendered supersensitive for the noradrenaline response by intraperitoneal injection of reserpine. There was no difference in the concentration-dependence of lithium inhibition between control and reserpine-treated rats.

Original languageEnglish
Pages (from-to)353-355
Number of pages3
JournalNeuropharmacology
Volume24
Issue number4
DOIs
StatePublished - 1 Jan 1985
Externally publishedYes

Keywords

  • cyclic AMP
  • lithium
  • noradrenaline
  • rat brain
  • reserpine

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