Effects of lycopene-enriched tomato oleoresin on 7,12-dimethyl-benz[a]anthracene-induced rat mammary tumors

Y. Sharoni, E. Giron, M. Rise, J. Levy

Research output: Contribution to journalArticlepeer-review

114 Scopus citations

Abstract

Consumption of carotenoids has frequently been inversely correlated with cancer incidence. In this report we used the 7,12-dimethyl-benz[a]anthracene (DMBA)-induced rat mammary tumor model to compare the effect of lycopene-enriched tomato oleoresin on the initiation and progression of these tumors with that of β-carotene. Rats were injected i.p. with lycopene-enriched tomato oleoresin or β-carotene (10 mg/kg, twice per week) for 2 weeks prior to tumor induction by DMBA and for an additional 16 weeks after carcinogen administration. HPLC analysis of carotenoids extracted from several tissues showed that both carotenoids were absorbed into blood, liver, mammary gland, and mammary tumors. The tomato oleoresin-treated rats developed significantly fewer tumors, and the tumor area was smaller than that of the unsupplemented rats. Rats receiving β-carotene showed no protection against the development of mammary cancer.

Original languageEnglish
Pages (from-to)118-123
Number of pages6
JournalCancer Detection and Prevention
Volume21
Issue number2
StatePublished - 1 Jan 1997

Keywords

  • 7,12-dimethyl-benz[a]anthracene
  • β-carotene

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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