Effects of maternal ritodrine therapy on fetal rat brain development

E. Zmora, D. L. Shapiro

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

The effects of maternal treatment with ritodrine, a β2-adrenergic agonist, on the biochemical development of fetal brain were studied in an animal model. Pregnant rats were treated with long and short dosage schedules. Fetuses were delivered by hysterotomy 4 h after the last dose. No differences in the fetal brain content of protein, DNA, glycogen, cholesterol or β-adrenergic receptors were found. In this animal model, using relatively high maternal doses of ritodrine, there were no apparent effects on the fetal brain biochemical indices measured, suggesting a relatively high efficacy to toxicity ratio of ritodrine for brain development.

Original languageEnglish
Pages (from-to)76-85
Number of pages10
JournalDevelopmental Pharmacology and Therapeutics
Volume5
Issue number1-2
DOIs
StatePublished - 1 Jan 1982
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics (all)
  • Pharmacology (medical)

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