Effects of maternal ritodrine therapy on fetal rat brain development

E. Zmora; D. L. Shapiro

doi:10.1159/000481010

Effects of maternal ritodrine therapy on fetal rat brain development

E. Zmora, D. L. Shapiro

Research output: Contribution to journal › Article › peer-review

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Abstract

The effects of maternal treatment with ritodrine, a β₂-adrenergic agonist, on the biochemical development of fetal brain were studied in an animal model. Pregnant rats were treated with long and short dosage schedules. Fetuses were delivered by hysterotomy 4 h after the last dose. No differences in the fetal brain content of protein, DNA, glycogen, cholesterol or β-adrenergic receptors were found. In this animal model, using relatively high maternal doses of ritodrine, there were no apparent effects on the fetal brain biochemical indices measured, suggesting a relatively high efficacy to toxicity ratio of ritodrine for brain development.

Original language	English
Pages (from-to)	76-85
Number of pages	10
Journal	Developmental Pharmacology and Therapeutics
Volume	5
Issue number	1-2
DOIs	https://doi.org/10.1159/000481010
State	Published - 1 Jan 1982
Externally published	Yes

ASJC Scopus subject areas

General Pharmacology, Toxicology and Pharmaceutics
Pharmacology (medical)

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AU - Shapiro, D. L.

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AB - The effects of maternal treatment with ritodrine, a β2-adrenergic agonist, on the biochemical development of fetal brain were studied in an animal model. Pregnant rats were treated with long and short dosage schedules. Fetuses were delivered by hysterotomy 4 h after the last dose. No differences in the fetal brain content of protein, DNA, glycogen, cholesterol or β-adrenergic receptors were found. In this animal model, using relatively high maternal doses of ritodrine, there were no apparent effects on the fetal brain biochemical indices measured, suggesting a relatively high efficacy to toxicity ratio of ritodrine for brain development.

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ER -

Effects of maternal ritodrine therapy on fetal rat brain development

Abstract

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