Effects of mutations in de novo designed synthetic amphiphilic β-sheet peptides on self-assembly of fibrils

Yoav Raz; Boris Rubinov; Maayan Matmor; Hanna Rapaport; Gonen Ashkenasy; Yifat Miller

doi:10.1039/c3cc42879f

Effects of mutations in de novo designed synthetic amphiphilic β-sheet peptides on self-assembly of fibrils

Yoav Raz, Boris Rubinov, Maayan Matmor, Hanna Rapaport, Gonen Ashkenasy, Yifat Miller

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

The self-assembly of two similar amphiphilic peptides into fibril structures is described. Molecular dynamic simulations show that both can organize similarly in a monolayer, but in the fibril bilayer, one prefers a single organization while the other forms two conformational variants. This assembly difference correlates well with our experimental results.

Original language	English
Pages (from-to)	6561-6563
Number of pages	3
Journal	Chemical Communications
Volume	49
Issue number	58
DOIs	https://doi.org/10.1039/c3cc42879f
State	Published - 25 Jun 2013

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

Access to Document

10.1039/c3cc42879f

Cite this

@article{c7fc532181354c39924f224c81a388f3,

title = "Effects of mutations in de novo designed synthetic amphiphilic β-sheet peptides on self-assembly of fibrils",

abstract = "The self-assembly of two similar amphiphilic peptides into fibril structures is described. Molecular dynamic simulations show that both can organize similarly in a monolayer, but in the fibril bilayer, one prefers a single organization while the other forms two conformational variants. This assembly difference correlates well with our experimental results.",

author = "Yoav Raz and Boris Rubinov and Maayan Matmor and Hanna Rapaport and Gonen Ashkenasy and Yifat Miller",

year = "2013",

month = jun,

day = "25",

doi = "10.1039/c3cc42879f",

language = "English",

volume = "49",

pages = "6561--6563",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "58",

}

TY - JOUR

T1 - Effects of mutations in de novo designed synthetic amphiphilic β-sheet peptides on self-assembly of fibrils

AU - Raz, Yoav

AU - Rubinov, Boris

AU - Matmor, Maayan

AU - Rapaport, Hanna

AU - Ashkenasy, Gonen

AU - Miller, Yifat

PY - 2013/6/25

Y1 - 2013/6/25

N2 - The self-assembly of two similar amphiphilic peptides into fibril structures is described. Molecular dynamic simulations show that both can organize similarly in a monolayer, but in the fibril bilayer, one prefers a single organization while the other forms two conformational variants. This assembly difference correlates well with our experimental results.

AB - The self-assembly of two similar amphiphilic peptides into fibril structures is described. Molecular dynamic simulations show that both can organize similarly in a monolayer, but in the fibril bilayer, one prefers a single organization while the other forms two conformational variants. This assembly difference correlates well with our experimental results.

UR - http://www.scopus.com/inward/record.url?scp=84879767217&partnerID=8YFLogxK

U2 - 10.1039/c3cc42879f

DO - 10.1039/c3cc42879f

M3 - Article

C2 - 23770891

AN - SCOPUS:84879767217

SN - 1359-7345

VL - 49

SP - 6561

EP - 6563

JO - Chemical Communications

JF - Chemical Communications

IS - 58

ER -

Effects of mutations in de novo designed synthetic amphiphilic β-sheet peptides on self-assembly of fibrils

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this