TY - JOUR
T1 - Effects of prostagiandin F2α or oxytocin on serum estriol and its conjugates during induced labor
AU - Young, B. K.
AU - Noumoff, J.
AU - Katz, M.
AU - Kadner, S.
AU - Levitz, M.
N1 - Funding Information:
This investigationw as supportedb y Public Health Service Grant CA 02071 from the National Cancer Institute,N ational Instituteso f Health and a grant from the Upjohn Company, Kalamazoo,M ichigan.
PY - 1981/1/1
Y1 - 1981/1/1
N2 - Twelve patients underwent induction of labor at term, seven by prostaglandin F2α (PGF) and five by oxytocin infusion. Serum samples were drawn before induction and at two hour intervals after infusion was started, throughout labor. The samples were analyzed for estriol (E3) and its principal conjugates, estriol-3-sulfate (E3-3S), estriol-16-glucosiduronate (E3-16G), estriol-3-glucosiduronate (E3-3G), and estriol-3-sulfate-16-glucosiduronate (E3-SG). No significant changes occurred before eight hours of infusion. Two pre-eclamptic patients showed a 100° increase in serum E3 while receiving PGF. The increases correlated best with rising levels of E3-SG.None of the five pre-eclamptic patients given oxytocin showed this striking change. These observations raise the possibility that PGF may alter the metabolism of estriol in pre-eclamptic patients, during labor.
AB - Twelve patients underwent induction of labor at term, seven by prostaglandin F2α (PGF) and five by oxytocin infusion. Serum samples were drawn before induction and at two hour intervals after infusion was started, throughout labor. The samples were analyzed for estriol (E3) and its principal conjugates, estriol-3-sulfate (E3-3S), estriol-16-glucosiduronate (E3-16G), estriol-3-glucosiduronate (E3-3G), and estriol-3-sulfate-16-glucosiduronate (E3-SG). No significant changes occurred before eight hours of infusion. Two pre-eclamptic patients showed a 100° increase in serum E3 while receiving PGF. The increases correlated best with rising levels of E3-SG.None of the five pre-eclamptic patients given oxytocin showed this striking change. These observations raise the possibility that PGF may alter the metabolism of estriol in pre-eclamptic patients, during labor.
UR - http://www.scopus.com/inward/record.url?scp=0019394068&partnerID=8YFLogxK
U2 - 10.1016/0161-4630(81)90149-X
DO - 10.1016/0161-4630(81)90149-X
M3 - Article
AN - SCOPUS:0019394068
SN - 0952-3278
VL - 6
SP - 257
EP - 265
JO - Prostaglandins Leukotrienes and Essential Fatty Acids
JF - Prostaglandins Leukotrienes and Essential Fatty Acids
IS - 3
ER -