Effects of salicylate and indomethacin in nonfebrile rats at different ambient temperatures

Alexander Solomonovich, Jacob Kaplanski

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


The effects of sodium salicylate (SS) and indomethacin (INDO) on rectal temperature (RT) and on prostaglandin (PG) concentration in the anterior hypothalamus of nonfebrile rats exposed to ambient temperatures (AT) of 4±1°C, 23±2°C and 34±2°C were investigated. In rats treated with SS and exposed to AT of 4°C and 23°C, RT decreased by 1 - 1.5°C (p<0.01). On the other hand at AT of 34°C, SS-treated rats had an elevation of RT of 2°C (p<0.01). However, in rats treated by INDO, RT did not change, in spite of significant decreases (p<0.01) in PGE2 under all three environmental conditions. In SS treated rats a significant decrease (p<0.01) of PGE2 was observed only at At 23°C, whereas hypothalamic PGE levels were not inhibited at 4°C or 34°C. This data do not support the hypothesis that PG is the mediator of normal thermoregulation in the rat. The changes in deep body temperature observed in nonfebrile rats treated with salicylate may be related to a mechanism that is not associated with PG cyclooxygenase inhibition.

Original languageEnglish
Pages (from-to)161-165
Number of pages5
JournalProstaglandins Leukotrienes and Essential Fatty Acids
Issue number2
StatePublished - 1 Jan 1985

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Endocrinology


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