TY - JOUR
T1 - Effects of salicylate and indomethacin in nonfebrile rats at different ambient temperatures
AU - Solomonovich, Alexander
AU - Kaplanski, Jacob
PY - 1985/1/1
Y1 - 1985/1/1
N2 - The effects of sodium salicylate (SS) and indomethacin (INDO) on rectal temperature (RT) and on prostaglandin (PG) concentration in the anterior hypothalamus of nonfebrile rats exposed to ambient temperatures (AT) of 4±1°C, 23±2°C and 34±2°C were investigated. In rats treated with SS and exposed to AT of 4°C and 23°C, RT decreased by 1 - 1.5°C (p<0.01). On the other hand at AT of 34°C, SS-treated rats had an elevation of RT of 2°C (p<0.01). However, in rats treated by INDO, RT did not change, in spite of significant decreases (p<0.01) in PGE2 under all three environmental conditions. In SS treated rats a significant decrease (p<0.01) of PGE2 was observed only at At 23°C, whereas hypothalamic PGE levels were not inhibited at 4°C or 34°C. This data do not support the hypothesis that PG is the mediator of normal thermoregulation in the rat. The changes in deep body temperature observed in nonfebrile rats treated with salicylate may be related to a mechanism that is not associated with PG cyclooxygenase inhibition.
AB - The effects of sodium salicylate (SS) and indomethacin (INDO) on rectal temperature (RT) and on prostaglandin (PG) concentration in the anterior hypothalamus of nonfebrile rats exposed to ambient temperatures (AT) of 4±1°C, 23±2°C and 34±2°C were investigated. In rats treated with SS and exposed to AT of 4°C and 23°C, RT decreased by 1 - 1.5°C (p<0.01). On the other hand at AT of 34°C, SS-treated rats had an elevation of RT of 2°C (p<0.01). However, in rats treated by INDO, RT did not change, in spite of significant decreases (p<0.01) in PGE2 under all three environmental conditions. In SS treated rats a significant decrease (p<0.01) of PGE2 was observed only at At 23°C, whereas hypothalamic PGE levels were not inhibited at 4°C or 34°C. This data do not support the hypothesis that PG is the mediator of normal thermoregulation in the rat. The changes in deep body temperature observed in nonfebrile rats treated with salicylate may be related to a mechanism that is not associated with PG cyclooxygenase inhibition.
UR - http://www.scopus.com/inward/record.url?scp=0021799869&partnerID=8YFLogxK
U2 - 10.1016/0262-1746(85)90082-4
DO - 10.1016/0262-1746(85)90082-4
M3 - Article
AN - SCOPUS:0021799869
SN - 0262-1746
VL - 19
SP - 161
EP - 165
JO - Prostaglandins Leukotrienes and Essential Fatty Acids
JF - Prostaglandins Leukotrienes and Essential Fatty Acids
IS - 2
ER -