Abstract
Arginine monochloride (5 g) was administered as a 2-min "pulse" to 24 normal male subjects. The amino acid-induced insulin release was maximal 2 min after the end of the pulse, and uniphasic in nature. A small rise in scrum glucose levels was observed starting 2 to S min after the pulse. Thus, the insulin-releasing and hyperglycemic properties of the amino acid were temporally dissociated in vivo. Repeated pulses of L-arginine-HCl (up to a maximum of 4) were at least equipotent in inducing insulin release. That is, there was no exhaustion of the pool of insulin acutely released after arginine.
| Original language | English |
|---|---|
| Pages (from-to) | 901-905 |
| Number of pages | 5 |
| Journal | Journal of Clinical Endocrinology and Metabolism |
| Volume | 36 |
| Issue number | 5 |
| DOIs | |
| State | Published - 1 Jan 1973 |
| Externally published | Yes |
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Biochemistry
- Endocrinology
- Clinical Biochemistry
- Biochemistry, medical