Effects of single and multiple pulses of arginine on insulin release in man

David Rabinowitz, Irving Spitz, Boaz Gonen, Esther Paran

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Arginine monochloride (5 g) was administered as a 2-min "pulse" to 24 normal male subjects. The amino acid-induced insulin release was maximal 2 min after the end of the pulse, and uniphasic in nature. A small rise in scrum glucose levels was observed starting 2 to S min after the pulse. Thus, the insulin-releasing and hyperglycemic properties of the amino acid were temporally dissociated in vivo. Repeated pulses of L-arginine-HCl (up to a maximum of 4) were at least equipotent in inducing insulin release. That is, there was no exhaustion of the pool of insulin acutely released after arginine.

Original languageEnglish
Pages (from-to)901-905
Number of pages5
JournalJournal of Clinical Endocrinology and Metabolism
Issue number5
StatePublished - 1 Jan 1973
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical


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