Effects of triiodothyronine and fluoxetine on 5-HT1A and 5-HT1B autoreceptor activity in rat brain: Regional differences

Tzuri Lifschytz; Eitan Gur; Bernard Lerer; Michael E. Newman

doi:10.1016/j.jneumeth.2004.03.028

Effects of triiodothyronine and fluoxetine on 5-HT_1A and 5-HT_1B autoreceptor activity in rat brain: Regional differences

Tzuri Lifschytz, Eitan Gur, Bernard Lerer, Michael E. Newman

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

The thyroid hormone triiodothyronine (T3) augments and accelerates the effects of antidepressant drugs. Although the majority of studies showing this have used tricyclics, a few studies have shown similar effects with the selective serotonin re-uptake inhibitor (SSRI) fluoxetine. In this study we investigated the effects of fluoxetine (5 mg/kg), T3 (20 μg/kg) and the combination of these drugs, each administered daily for 7 days, on serotonergic function in the rat brain, using in vivo microdialysis. Fluoxetine alone induced a trend towards desensitization of 5-HT_1A autoreceptors as shown by a reduction in the effect of 8-OH-DPAT to lower 5-HT levels in frontal cortex, and desensitized 5-HT_1B autoreceptors in frontal cortex. The combination of fluoxetine and T3 induced desensitization of 5-HT_1B autoreceptors in hypothalamus. Since there is evidence linking hypothalamic function and depression, we suggest that this effect may partly account for the therapeutic efficacy of the combination of an SSRI and T3.

Original language	English
Pages (from-to)	133-139
Number of pages	7
Journal	Journal of Neuroscience Methods
Volume	140
Issue number	1-2 SPEC. ISS.
DOIs	https://doi.org/10.1016/j.jneumeth.2004.03.028
State	Published - 30 Dec 2004
Externally published	Yes

Keywords

Antidepressant
Fluoxetine
Microdialysis
Serotonin
Triiodothyronine

ASJC Scopus subject areas

General Neuroscience

Access to Document

10.1016/j.jneumeth.2004.03.028

Cite this

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title = "Effects of triiodothyronine and fluoxetine on 5-HT1A and 5-HT1B autoreceptor activity in rat brain: Regional differences",

abstract = "The thyroid hormone triiodothyronine (T3) augments and accelerates the effects of antidepressant drugs. Although the majority of studies showing this have used tricyclics, a few studies have shown similar effects with the selective serotonin re-uptake inhibitor (SSRI) fluoxetine. In this study we investigated the effects of fluoxetine (5 mg/kg), T3 (20 μg/kg) and the combination of these drugs, each administered daily for 7 days, on serotonergic function in the rat brain, using in vivo microdialysis. Fluoxetine alone induced a trend towards desensitization of 5-HT1A autoreceptors as shown by a reduction in the effect of 8-OH-DPAT to lower 5-HT levels in frontal cortex, and desensitized 5-HT1B autoreceptors in frontal cortex. The combination of fluoxetine and T3 induced desensitization of 5-HT1B autoreceptors in hypothalamus. Since there is evidence linking hypothalamic function and depression, we suggest that this effect may partly account for the therapeutic efficacy of the combination of an SSRI and T3.",

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