EFFICACY OF SHORT‐CONTACT THERAPY WITH DITHRANOL IN CHILDHOOD PSORIASIS

ALEXANDER ZVULUNOV, AMIR ANISFELD, ARIEH METZKER

Research output: Contribution to journalArticlepeer-review

54 Scopus citations

Abstract

Background. Dithranol is a potent reducing substance and is thought to achieve its effect on psoriasis by reduction of cell turnover. It was shown to be efficacious in adults, but its efficacy has not been documented in children. Methods. The efficacy of short‐contact therapy, a dithranol cream preparation, was retrospectively evaluated in 58 children with psoriasis. Dithranol cream (0.1‐2%) was applied daily for 30 minutes to affected skin areas. Patients were evaluated at 1‐4‐week intervals. Results. The median duration of therapy before the onset of remission was 2 months. Remission was achieved in 81% of the children. The median duration of remission was 4 months. Mild adverse skin reactions occurred in 20% of patients, but only one patient had to discontinue therapy. Conclusion. Short‐contact therapy with dithranol cream preparation is an effective and well‐tolerated treatment for childhood psoriasis. A thorough explanation of the disease and mode of therapy to patients and their parents is essential for good compliance and subsequent success.

Original languageEnglish
Pages (from-to)808-810
Number of pages3
JournalInternational Journal of Dermatology
Volume33
Issue number11
DOIs
StatePublished - 1 Jan 1994
Externally publishedYes

ASJC Scopus subject areas

  • Dermatology

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