Efficient catalyst-free Domino approach for the synthesis of novel 2-benzazepine derivatives in water

J. Venkata Prasad; Maddela Prabhakar; K. Manjulatha; D. Rambabu; K. Anand Solomon; G. Gopi Krishna; K. Anil Kumar

doi:10.1016/j.tetlet.2010.04.020

Efficient catalyst-free Domino approach for the synthesis of novel 2-benzazepine derivatives in water

J. Venkata Prasad, Maddela Prabhakar, K. Manjulatha, D. Rambabu, K. Anand Solomon, G. Gopi Krishna, K. Anil Kumar

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

A novel one-pot eco-friendly protocol for the synthesis of 2-benzazepine derivatives in water has been developed. 4-Chloro-3-formyl coumarin reacts with benzyl amines under catalyst-free conditions in aqueous medium to afford substituted 5-(2′-hydroxyaryl)-4-amido-2-benzazepines in excellent yields.

Original language	English
Pages (from-to)	3109-3111
Number of pages	3
Journal	Tetrahedron Letters
Volume	51
Issue number	23
DOIs	https://doi.org/10.1016/j.tetlet.2010.04.020
State	Published - 9 Jun 2010
Externally published	Yes

Keywords

Benzazepines
Benzyl amines
Catalyst-free
Coumarin
Green chemistry
One-pot synthesis
Scaffold hopping

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

Access to Document

10.1016/j.tetlet.2010.04.020

Cite this

@article{990c6b0b66d2460a9d2eeff8252ac8c8,

title = "Efficient catalyst-free Domino approach for the synthesis of novel 2-benzazepine derivatives in water",

abstract = "A novel one-pot eco-friendly protocol for the synthesis of 2-benzazepine derivatives in water has been developed. 4-Chloro-3-formyl coumarin reacts with benzyl amines under catalyst-free conditions in aqueous medium to afford substituted 5-(2′-hydroxyaryl)-4-amido-2-benzazepines in excellent yields.",

keywords = "Benzazepines, Benzyl amines, Catalyst-free, Coumarin, Green chemistry, One-pot synthesis, Scaffold hopping",

author = "\{Venkata Prasad\}, J. and Maddela Prabhakar and K. Manjulatha and D. Rambabu and \{Anand Solomon\}, K. and \{Gopi Krishna\}, G. and \{Anil Kumar\}, K.",

year = "2010",

month = jun,

day = "9",

doi = "10.1016/j.tetlet.2010.04.020",

language = "English",

volume = "51",

pages = "3109--3111",

journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Elsevier Ltd.",

number = "23",

}

TY - JOUR

T1 - Efficient catalyst-free Domino approach for the synthesis of novel 2-benzazepine derivatives in water

AU - Venkata Prasad, J.

AU - Prabhakar, Maddela

AU - Manjulatha, K.

AU - Rambabu, D.

AU - Anand Solomon, K.

AU - Gopi Krishna, G.

AU - Anil Kumar, K.

PY - 2010/6/9

Y1 - 2010/6/9

N2 - A novel one-pot eco-friendly protocol for the synthesis of 2-benzazepine derivatives in water has been developed. 4-Chloro-3-formyl coumarin reacts with benzyl amines under catalyst-free conditions in aqueous medium to afford substituted 5-(2′-hydroxyaryl)-4-amido-2-benzazepines in excellent yields.

AB - A novel one-pot eco-friendly protocol for the synthesis of 2-benzazepine derivatives in water has been developed. 4-Chloro-3-formyl coumarin reacts with benzyl amines under catalyst-free conditions in aqueous medium to afford substituted 5-(2′-hydroxyaryl)-4-amido-2-benzazepines in excellent yields.

KW - Benzazepines

KW - Benzyl amines

KW - Catalyst-free

KW - Coumarin

KW - Green chemistry

KW - One-pot synthesis

KW - Scaffold hopping

UR - https://www.scopus.com/pages/publications/77953123150

U2 - 10.1016/j.tetlet.2010.04.020

DO - 10.1016/j.tetlet.2010.04.020

M3 - Article

AN - SCOPUS:77953123150

SN - 0040-4039

VL - 51

SP - 3109

EP - 3111

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 23

ER -

Efficient catalyst-free Domino approach for the synthesis of novel 2-benzazepine derivatives in water

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this