TY - JOUR
T1 - Elastin-Like Peptides (ELPs) – Building Blocks for Stimuli-Responsive Self-Assembled Materials
AU - Navon, Yotam
AU - Bitton, Ronit
N1 - Publisher Copyright:
© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
PY - 2016/8/1
Y1 - 2016/8/1
N2 - Elastin-like polypeptides (ELPs) are biopolymers composed of short repeating peptide motifs inspired by the native elastin hydrophobic domains, mostly the pentapeptide VPGXG, where X is a guest residue, which can be any amino acid except proline. The ability to control the hydrophobicity of ELPs, simply by changing the guest residue, and moreover, to transform an ELP from a soluble molecule to an insoluble one upon heating, makes them promising building blocks for novel stimuli-responsive self-assembled materials. Over the past decade, ELPs have been designed to self-assemble into spherical and cylindrical micelles, fibres, vesicles, and coacervates. In this short review, we summarize the recent literature, describing the molecules and conditions employed to attain these desired structures.
AB - Elastin-like polypeptides (ELPs) are biopolymers composed of short repeating peptide motifs inspired by the native elastin hydrophobic domains, mostly the pentapeptide VPGXG, where X is a guest residue, which can be any amino acid except proline. The ability to control the hydrophobicity of ELPs, simply by changing the guest residue, and moreover, to transform an ELP from a soluble molecule to an insoluble one upon heating, makes them promising building blocks for novel stimuli-responsive self-assembled materials. Over the past decade, ELPs have been designed to self-assemble into spherical and cylindrical micelles, fibres, vesicles, and coacervates. In this short review, we summarize the recent literature, describing the molecules and conditions employed to attain these desired structures.
KW - ELP
KW - Elastin
KW - materials science
KW - self-assembly
KW - thermoresponsive
UR - http://www.scopus.com/inward/record.url?scp=84961711430&partnerID=8YFLogxK
U2 - 10.1002/ijch.201500016
DO - 10.1002/ijch.201500016
M3 - Review article
AN - SCOPUS:84961711430
SN - 0021-2148
VL - 56
SP - 581
EP - 589
JO - Israel Journal of Chemistry
JF - Israel Journal of Chemistry
IS - 8
ER -