Electro-reduced graphene oxide film modified glassy carbon electrode as an electrochemical sensor for sibutramine

Nagappa L. Teradal; Prashanth S. Narayan; Seetharamappa Jaladappagari

doi:10.1039/c3ay41575a

Electro-reduced graphene oxide film modified glassy carbon electrode as an electrochemical sensor for sibutramine

Nagappa L. Teradal, Prashanth S. Narayan, Seetharamappa Jaladappagari

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

In the present study, the electrochemical behavior of an anorexiant drug, sibutramine (SHM), was studied at an electro-reduced graphene oxide film modified glassy carbon electrode (ERGO-GCE) for the first time. SHM exhibited two irreversible oxidation peaks at 0.620 V and 0.835 V in Britton-Robinson buffer in the pH range 3-10. The first peak and second peak were found to result from adsorption and diffusion controlled processes, respectively. ERGO-GCE exhibited excellent electrocatalytic activity for the oxidation of SHM. Under optimized experimental conditions, the oxidation peak (a₂) current was observed to be proportional to the concentration of SHM up to 2.00 × 10^-5 mol L^-1 with a limit of detection of 4.80 × 10^-8 mol L^-1. The proposed sensor was successfully applied for the assay of SHM in analyte fortified human serum and urine samples. No interference was evident from endogenous substances present in biological fluids.

Original language	English
Pages (from-to)	7090-7095
Number of pages	6
Journal	Analytical Methods
Volume	5
Issue number	24
DOIs	https://doi.org/10.1039/c3ay41575a
State	Published - 2 Dec 2013
Externally published	Yes

ASJC Scopus subject areas

Analytical Chemistry
General Chemical Engineering
General Engineering

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10.1039/c3ay41575a

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title = "Electro-reduced graphene oxide film modified glassy carbon electrode as an electrochemical sensor for sibutramine",

abstract = "In the present study, the electrochemical behavior of an anorexiant drug, sibutramine (SHM), was studied at an electro-reduced graphene oxide film modified glassy carbon electrode (ERGO-GCE) for the first time. SHM exhibited two irreversible oxidation peaks at 0.620 V and 0.835 V in Britton-Robinson buffer in the pH range 3-10. The first peak and second peak were found to result from adsorption and diffusion controlled processes, respectively. ERGO-GCE exhibited excellent electrocatalytic activity for the oxidation of SHM. Under optimized experimental conditions, the oxidation peak (a2) current was observed to be proportional to the concentration of SHM up to 2.00 × 10-5 mol L-1 with a limit of detection of 4.80 × 10-8 mol L-1. The proposed sensor was successfully applied for the assay of SHM in analyte fortified human serum and urine samples. No interference was evident from endogenous substances present in biological fluids.",

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AU - Teradal, Nagappa L.

AU - Narayan, Prashanth S.

AU - Jaladappagari, Seetharamappa

PY - 2013/12/2

Y1 - 2013/12/2

N2 - In the present study, the electrochemical behavior of an anorexiant drug, sibutramine (SHM), was studied at an electro-reduced graphene oxide film modified glassy carbon electrode (ERGO-GCE) for the first time. SHM exhibited two irreversible oxidation peaks at 0.620 V and 0.835 V in Britton-Robinson buffer in the pH range 3-10. The first peak and second peak were found to result from adsorption and diffusion controlled processes, respectively. ERGO-GCE exhibited excellent electrocatalytic activity for the oxidation of SHM. Under optimized experimental conditions, the oxidation peak (a2) current was observed to be proportional to the concentration of SHM up to 2.00 × 10-5 mol L-1 with a limit of detection of 4.80 × 10-8 mol L-1. The proposed sensor was successfully applied for the assay of SHM in analyte fortified human serum and urine samples. No interference was evident from endogenous substances present in biological fluids.

AB - In the present study, the electrochemical behavior of an anorexiant drug, sibutramine (SHM), was studied at an electro-reduced graphene oxide film modified glassy carbon electrode (ERGO-GCE) for the first time. SHM exhibited two irreversible oxidation peaks at 0.620 V and 0.835 V in Britton-Robinson buffer in the pH range 3-10. The first peak and second peak were found to result from adsorption and diffusion controlled processes, respectively. ERGO-GCE exhibited excellent electrocatalytic activity for the oxidation of SHM. Under optimized experimental conditions, the oxidation peak (a2) current was observed to be proportional to the concentration of SHM up to 2.00 × 10-5 mol L-1 with a limit of detection of 4.80 × 10-8 mol L-1. The proposed sensor was successfully applied for the assay of SHM in analyte fortified human serum and urine samples. No interference was evident from endogenous substances present in biological fluids.

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Electro-reduced graphene oxide film modified glassy carbon electrode as an electrochemical sensor for sibutramine

Abstract

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