Electrochemical studies of nevirapine, an anti-hiv drug, and its assay in tablets and biological samples

Nagappa Laxman Teradal, Shankar Narayan Prashanth, Jaldappagari Seetharamappa

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


The electrochemical oxidation of nevirapine, an anti-HIV drug, at a glassy carbon electrode has been studied by voltammetric techniques. Nevirapine showed one well defined irreversible oxidation peak with a potential of 0.749 V in phosphate buffer at pH 10. The effects of different electrolytes, pH and scan rate on the electrochemical behaviour of nevirapine were examined to determine the optimum reaction conditions. The oxidation peak current was found to vary linearly with the concentration of nevirapine in the range of 5.0 – 350 µM. The limit of detection and limit of quantification values were calculated and found to be 1.026 µM and 3.420 µM, respectively. The low relative standard deviation values of inter-day and intra-day assays highlighted the good reproducibility of the proposed method for assay of nevirapine. Further, a sensitive and accurate differential pulse voltammetric method was developed for the determination of nevirapine concentrations in pharmaceutical formulations.

Original languageEnglish
Pages (from-to)67-75
Number of pages9
JournalJournal of Electrochemical Science and Engineering
Issue number2
StatePublished - 18 Jun 2012
Externally publishedYes


  • Nevirapine
  • Non-nucleoside inhibitor
  • Pharmaceutical formulations
  • Voltammetric investigations

ASJC Scopus subject areas

  • Chemical Engineering (miscellaneous)
  • Colloid and Surface Chemistry
  • Materials Chemistry
  • Electrochemistry


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