Electroconvulsive shock prevents dopamine receptor supersensitivity

Bernard Lerer, Karni Jabotinsky-Rubin, Jacob Bannet, Richard P. Ebstein, Robert H. Belmaker

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Electroconvulsive shock has been reported to increase dopamine receptor sensitivity as measured behaviorally, but no change could previously be measured biochemically. When chronic haloperidol treatment was used to induce supersensitivity as model of exogenous or pathologic receptor changes, electroconvulsive shock was found to stabilize the dopamine receptor both biochemically and behaviorally.

Original languageEnglish
Pages (from-to)131-134
Number of pages4
JournalEuropean Journal of Pharmacology
Volume80
Issue number1
DOIs
StatePublished - 7 May 1982
Externally publishedYes

Keywords

  • Dopamine receptors
  • Electroconvulsive shock
  • Haloperidol

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