Electroconvulsive shock prevents dopamine receptor supersensitivity

Bernard Lerer; Karni Jabotinsky-Rubin; Jacob Bannet; Richard P. Ebstein; Robert H. Belmaker

doi:10.1016/0014-2999(82)90188-1

Electroconvulsive shock prevents dopamine receptor supersensitivity

Bernard Lerer
, Karni Jabotinsky-Rubin
, Jacob Bannet
, Richard P. Ebstein
, Robert H. Belmaker

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Electroconvulsive shock has been reported to increase dopamine receptor sensitivity as measured behaviorally, but no change could previously be measured biochemically. When chronic haloperidol treatment was used to induce supersensitivity as model of exogenous or pathologic receptor changes, electroconvulsive shock was found to stabilize the dopamine receptor both biochemically and behaviorally.

Original language	English
Pages (from-to)	131-134
Number of pages	4
Journal	European Journal of Pharmacology
Volume	80
Issue number	1
DOIs	https://doi.org/10.1016/0014-2999(82)90188-1
State	Published - 7 May 1982
Externally published	Yes

Keywords

Dopamine receptors
Electroconvulsive shock
Haloperidol

ASJC Scopus subject areas

Pharmacology

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10.1016/0014-2999(82)90188-1

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title = "Electroconvulsive shock prevents dopamine receptor supersensitivity",

abstract = "Electroconvulsive shock has been reported to increase dopamine receptor sensitivity as measured behaviorally, but no change could previously be measured biochemically. When chronic haloperidol treatment was used to induce supersensitivity as model of exogenous or pathologic receptor changes, electroconvulsive shock was found to stabilize the dopamine receptor both biochemically and behaviorally.",

keywords = "Dopamine receptors, Electroconvulsive shock, Haloperidol",

author = "Bernard Lerer and Karni Jabotinsky-Rubin and Jacob Bannet and Ebstein, \{Richard P.\} and Belmaker, \{Robert H.\}",

year = "1982",

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doi = "10.1016/0014-2999(82)90188-1",

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AU - Lerer, Bernard

AU - Jabotinsky-Rubin, Karni

AU - Bannet, Jacob

AU - Ebstein, Richard P.

AU - Belmaker, Robert H.

PY - 1982/5/7

Y1 - 1982/5/7

N2 - Electroconvulsive shock has been reported to increase dopamine receptor sensitivity as measured behaviorally, but no change could previously be measured biochemically. When chronic haloperidol treatment was used to induce supersensitivity as model of exogenous or pathologic receptor changes, electroconvulsive shock was found to stabilize the dopamine receptor both biochemically and behaviorally.

AB - Electroconvulsive shock has been reported to increase dopamine receptor sensitivity as measured behaviorally, but no change could previously be measured biochemically. When chronic haloperidol treatment was used to induce supersensitivity as model of exogenous or pathologic receptor changes, electroconvulsive shock was found to stabilize the dopamine receptor both biochemically and behaviorally.

KW - Dopamine receptors

KW - Electroconvulsive shock

KW - Haloperidol

UR - https://www.scopus.com/pages/publications/0020072635

U2 - 10.1016/0014-2999(82)90188-1

DO - 10.1016/0014-2999(82)90188-1

M3 - Article

AN - SCOPUS:0020072635

SN - 0014-2999

VL - 80

SP - 131

EP - 134

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

IS - 1

ER -

Electroconvulsive shock prevents dopamine receptor supersensitivity

Abstract

Keywords

ASJC Scopus subject areas

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