Electron-capture dissociation and collisioninduced dissociation fragmentation of the supermetallized complexes of Substance P with potassium, cesium and silver

Yury Kostyukevich, Alexander Zherebker, Alexey Kononikhin, Maria Indeykina, Igor Popov, Eugene Nikolaev

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

We report the investigation of the collision-induced dissociation (CID) and electron-capture dissociation (ECD) product fragmentations of the supermetallized complexes of Substance P and several monovalent metals. The supermetallization is the phenomenon of the formation of the complex ion peptide-metals in the gas phase when the peptide accepts an unexpectedly large number of metals. We have obtained and investigated complexes with the incorporation of up to four cesium (Cs), up to five potassium (K) and up to six silver (Ag) atoms. The current research reveals crucial changes in the complex behavior in the cases of different metals. It was observed that in CID spectra of complexes with Cs and K is dominated by the peak corresponding to the loss of metal cation while ECD gives a rich fragmentation. In the case of complexes with Ag, the loss of Ag+ occurs in ECD while the CID shows a good fragmentation.

Original languageEnglish
Pages (from-to)91-95
Number of pages5
JournalEuropean Journal of Mass Spectrometry
Volume22
Issue number2
DOIs
StatePublished - 24 Mar 2016
Externally publishedYes

Keywords

  • ESI
  • FT-ICR
  • Mass spectrometry
  • Metal ions
  • Metal-peptide complexes

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Spectroscopy

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