Electrophoresis of platelet monoamine oxidase in schizophrenia and manic‐depressive illness

R. H. Belmaker; R. Ebstein; R. Rimon; R. J. Wyatt; D. L. Murphy

doi:10.1111/j.1600-0447.1976.tb00094.x

Electrophoresis of platelet monoamine oxidase in schizophrenia and manic‐depressive illness

R. H. Belmaker, R. Ebstein, R. Rimon, R. J. Wyatt, D. L. Murphy

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Monoamine oxidase is an important enzyme in the catabolism of biogenic amines and can be measured in human platelets. Platelet MAO has been reported to be reduced in schizophrenic and manicdepressive patients, though other reports are contradictory. The present study evaluated the possibility that qualitative genetic enzyme abnormalities of MAO could be responsible for the different enzyme activities of platelet MAO in different populations. However, polyacrylamide gel electrophoresis of platelet MAO from 10 manic‐depressive, 12 schizophrenic, and 11 normal individuals did not reveal any genetic mutant forms.

Original language	English
Pages (from-to)	67-72
Number of pages	6
Journal	Acta Psychiatrica Scandinavica
Volume	54
Issue number	1
DOIs	https://doi.org/10.1111/j.1600-0447.1976.tb00094.x
State	Published - 1 Jan 1976
Externally published	Yes

Keywords

Monoamine oxidase
depression
electrophoresis
mania
platelet
schizophrenia

ASJC Scopus subject areas

Psychiatry and Mental health

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10.1111/j.1600-0447.1976.tb00094.x

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AU - Ebstein, R.

AU - Rimon, R.

AU - Wyatt, R. J.

AU - Murphy, D. L.

PY - 1976/1/1

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N2 - Monoamine oxidase is an important enzyme in the catabolism of biogenic amines and can be measured in human platelets. Platelet MAO has been reported to be reduced in schizophrenic and manicdepressive patients, though other reports are contradictory. The present study evaluated the possibility that qualitative genetic enzyme abnormalities of MAO could be responsible for the different enzyme activities of platelet MAO in different populations. However, polyacrylamide gel electrophoresis of platelet MAO from 10 manic‐depressive, 12 schizophrenic, and 11 normal individuals did not reveal any genetic mutant forms.

AB - Monoamine oxidase is an important enzyme in the catabolism of biogenic amines and can be measured in human platelets. Platelet MAO has been reported to be reduced in schizophrenic and manicdepressive patients, though other reports are contradictory. The present study evaluated the possibility that qualitative genetic enzyme abnormalities of MAO could be responsible for the different enzyme activities of platelet MAO in different populations. However, polyacrylamide gel electrophoresis of platelet MAO from 10 manic‐depressive, 12 schizophrenic, and 11 normal individuals did not reveal any genetic mutant forms.

KW - Monoamine oxidase

KW - depression

KW - electrophoresis

KW - mania

KW - platelet

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ER -

Electrophoresis of platelet monoamine oxidase in schizophrenia and manic‐depressive illness

Abstract

Keywords

ASJC Scopus subject areas

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