Electrophoresis of platelet monoamine oxidase in schizophrenia and manic‐depressive illness

R. H. Belmaker, R. Ebstein, R. Rimon, R. J. Wyatt, D. L. Murphy

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Monoamine oxidase is an important enzyme in the catabolism of biogenic amines and can be measured in human platelets. Platelet MAO has been reported to be reduced in schizophrenic and manicdepressive patients, though other reports are contradictory. The present study evaluated the possibility that qualitative genetic enzyme abnormalities of MAO could be responsible for the different enzyme activities of platelet MAO in different populations. However, polyacrylamide gel electrophoresis of platelet MAO from 10 manic‐depressive, 12 schizophrenic, and 11 normal individuals did not reveal any genetic mutant forms.

Original languageEnglish
Pages (from-to)67-72
Number of pages6
JournalActa Psychiatrica Scandinavica
Issue number1
StatePublished - 1 Jan 1976
Externally publishedYes


  • Monoamine oxidase
  • depression
  • electrophoresis
  • mania
  • platelet
  • schizophrenia

ASJC Scopus subject areas

  • Psychiatry and Mental health


Dive into the research topics of 'Electrophoresis of platelet monoamine oxidase in schizophrenia and manic‐depressive illness'. Together they form a unique fingerprint.

Cite this