Electrophoretic pattern of red blood cell catechol O methyltransferase in schizophrenia and manic depressive illness

R. Ebstein, R. H. Belmaker, D. Benbenisty, R. Rimon

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Human red blood cell (RBC) catechol O methyltransferase (COMT) was analyzed by polyacrylamide gel electrophoresis (PAGE). One major enzyme band (B) is observed after electrophoresis. In addition, a minor band (A) of COMT activity comprising no more than 25% of the total activity, is also detectable. The rate of migration during electrophoresis of both bands of RBC COMT was the same in manic depressive, schizophrenic, and normal individuals. These results did not reveal genetic variations in the COMT molecule among these three groups. Furthermore, when total RBC COMT was measured there were no statistically significant differences between schizophrenic, manic depressive, and control individuals.

Original languageEnglish
Pages (from-to)613-623
Number of pages11
JournalBiological Psychiatry
Volume11
Issue number5
StatePublished - 1 Dec 1976
Externally publishedYes

ASJC Scopus subject areas

  • Biological Psychiatry

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