Abstract
The power of independence: When exhibited on the surface of self-assembling peptide-amphiphile nanofibers, the hydrophobic laminin-derived IKVAV epitope induced nanofiber bundling through interdigitation with neighboring fibers and thus decreased the bioactivity of the resulting materials. The inclusion of charged amino acids in the peptide amphiphiles disrupted the tendency to bundle and led to significantly enhanced neurite outgrowth (see picture).
Original language | English |
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Pages (from-to) | 6292-6295 |
Number of pages | 4 |
Journal | Angewandte Chemie - International Edition |
Volume | 50 |
Issue number | 28 |
DOIs | |
State | Published - 4 Jul 2011 |
Externally published | Yes |
Keywords
- aggregation
- biological activity
- nanostructures
- peptides
- self-assembly
ASJC Scopus subject areas
- Catalysis
- General Chemistry