Elevated levels of hyaluronic acid in the sera of women with fibromyalgia

Ilana Yaron, Dan Buskila, Idit Shirazi, Lily Neumann, Ori Elkayam, Daphna Paran, Michael Yaron

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


Objective. To evaluate serum levels of hyaluronic acid (HA) in patients with fibromyalgia (FM). Methods. HA serum levels were evaluated by a radiometric assay in 42 women with FM (ACR criteria), 27 female patients with rheumatoid arthritis (RA) and 36 healthy female controls matched for age. Results. HA serum levels (mean μg/l ± SEM) were 41 ± 8.7 in healthy controls; 113 ± 15.9 in RA; and 420 ± 26 in FM. Conclusion. HA serum levels in women with FM were significantly elevated compared to healthy controls and patients with RA. This observation suggests that FM is associated with a biochemical abnormality and that serum HA could be a laboratory marker for its diagnosis.

Original languageEnglish
Pages (from-to)2221-2224
Number of pages4
JournalJournal of Rheumatology
Issue number11
StatePublished - 1 Nov 1997


  • Fibromyalgia
  • Hyaluronic acid

ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Immunology


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