Elevated levels of hyaluronic acid in the sera of women with fibromyalgia

Ilana Yaron; Dan Buskila; Idit Shirazi; Lily Neumann; Ori Elkayam; Daphna Paran; Michael Yaron

Elevated levels of hyaluronic acid in the sera of women with fibromyalgia

Ilana Yaron, Dan Buskila, Idit Shirazi, Lily Neumann, Ori Elkayam, Daphna Paran, Michael Yaron

Department of Epidemiology, Biostatistics and Community Health Sciences

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Objective. To evaluate serum levels of hyaluronic acid (HA) in patients with fibromyalgia (FM). Methods. HA serum levels were evaluated by a radiometric assay in 42 women with FM (ACR criteria), 27 female patients with rheumatoid arthritis (RA) and 36 healthy female controls matched for age. Results. HA serum levels (mean μg/l ± SEM) were 41 ± 8.7 in healthy controls; 113 ± 15.9 in RA; and 420 ± 26 in FM. Conclusion. HA serum levels in women with FM were significantly elevated compared to healthy controls and patients with RA. This observation suggests that FM is associated with a biochemical abnormality and that serum HA could be a laboratory marker for its diagnosis.

Original language	English
Pages (from-to)	2221-2224
Number of pages	4
Journal	Journal of Rheumatology
Volume	24
Issue number	11
State	Published - 1 Nov 1997

Keywords

Fibromyalgia
Hyaluronic acid

ASJC Scopus subject areas

Immunology and Allergy
Rheumatology
Immunology

Cite this

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title = "Elevated levels of hyaluronic acid in the sera of women with fibromyalgia",

abstract = "Objective. To evaluate serum levels of hyaluronic acid (HA) in patients with fibromyalgia (FM). Methods. HA serum levels were evaluated by a radiometric assay in 42 women with FM (ACR criteria), 27 female patients with rheumatoid arthritis (RA) and 36 healthy female controls matched for age. Results. HA serum levels (mean μg/l ± SEM) were 41 ± 8.7 in healthy controls; 113 ± 15.9 in RA; and 420 ± 26 in FM. Conclusion. HA serum levels in women with FM were significantly elevated compared to healthy controls and patients with RA. This observation suggests that FM is associated with a biochemical abnormality and that serum HA could be a laboratory marker for its diagnosis.",

keywords = "Fibromyalgia, Hyaluronic acid",

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T1 - Elevated levels of hyaluronic acid in the sera of women with fibromyalgia

AU - Yaron, Ilana

AU - Buskila, Dan

AU - Shirazi, Idit

AU - Neumann, Lily

AU - Elkayam, Ori

AU - Paran, Daphna

AU - Yaron, Michael

PY - 1997/11/1

Y1 - 1997/11/1

N2 - Objective. To evaluate serum levels of hyaluronic acid (HA) in patients with fibromyalgia (FM). Methods. HA serum levels were evaluated by a radiometric assay in 42 women with FM (ACR criteria), 27 female patients with rheumatoid arthritis (RA) and 36 healthy female controls matched for age. Results. HA serum levels (mean μg/l ± SEM) were 41 ± 8.7 in healthy controls; 113 ± 15.9 in RA; and 420 ± 26 in FM. Conclusion. HA serum levels in women with FM were significantly elevated compared to healthy controls and patients with RA. This observation suggests that FM is associated with a biochemical abnormality and that serum HA could be a laboratory marker for its diagnosis.

AB - Objective. To evaluate serum levels of hyaluronic acid (HA) in patients with fibromyalgia (FM). Methods. HA serum levels were evaluated by a radiometric assay in 42 women with FM (ACR criteria), 27 female patients with rheumatoid arthritis (RA) and 36 healthy female controls matched for age. Results. HA serum levels (mean μg/l ± SEM) were 41 ± 8.7 in healthy controls; 113 ± 15.9 in RA; and 420 ± 26 in FM. Conclusion. HA serum levels in women with FM were significantly elevated compared to healthy controls and patients with RA. This observation suggests that FM is associated with a biochemical abnormality and that serum HA could be a laboratory marker for its diagnosis.

KW - Fibromyalgia

KW - Hyaluronic acid

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SN - 0315-162X

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ER -

Elevated levels of hyaluronic acid in the sera of women with fibromyalgia

Abstract

Keywords

ASJC Scopus subject areas

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