TY - JOUR
T1 - Elevated serum immunoreactive pancreatic cationic trypsinogen in acute malnutrition
T2 - Evidence of pancreatic damage
AU - Durie, Peter R.
AU - Forstner, Gordon G.
AU - Gaskin, Kevin J.
AU - Weizman, Zvi
AU - Kopelman, Hinda R.
AU - Ellis, Lynda
AU - Largman, Corey
N1 - Funding Information:
From the Division of Gastroenterology, the Research Institute, The Hospital for Sick Children; the Department of Pediatrics, University of Toronto; the Departments of lnternal Medicine and Biological Chemistry, University of California, Davis; and the Biochemistry Research Laboratory, VA Medical Center, Martinez. California. Supported by research grants from the Medical Research Council of Canada (MA-6752) and from the Canadian Cystic Fibrosis Foundation. Drs. Hinda Kopelman and Zvi Weizman were recipient s of fellowship awards from the Canadian Cystic Fibrosis Foundation. Submitted for publication March 12, 1984; accepted July 13, 1984. Reprint requests: Peter R. Durie, M.D., Division of Gastroenterology, The Hospital for Sick Children, 555 University Ave.. Toronto, Ontario, Canada M5G 1X8.
PY - 1985/1/1
Y1 - 1985/1/1
N2 - We used a sensitive probe of pancreatic dysfunction, serum immunoreactive cationic trypsinogen, to study 50 infants and children with varying degrees of malnutrition. Patients were classified into subgroups according to the severity of malnutrition. Mean serum trypsinogen concentration was significantly elevated in 25 patients with "severe" malnutrition (77.4±42.0 ng/ml, P<0.001) and in 23 with "moderate" malnutrition (55.2±16.1 ng/ml, P<0.02) compared with the mean value (32.5±10.4 ng/ml) for well-nourished controls. The level of circulating trypsinogen tended to rise with increasing severity of malnutrition. There was no relationship between serum trypsinogen and other variables such as age, specific diagnosis, or mode of feeling. Elevated serum trypsinogen levels could not be atributed to renal disease or cystic fibrosis. In patients who showed an improvement in nutritional status, serum trypsinogen tended to revert toward normal. Elevated serum trypsinogen values in acutely malnourished infants and children may results from pancreatic acinar cell damage or regurgitation of enzymes from obstructed pancreatic ducts.
AB - We used a sensitive probe of pancreatic dysfunction, serum immunoreactive cationic trypsinogen, to study 50 infants and children with varying degrees of malnutrition. Patients were classified into subgroups according to the severity of malnutrition. Mean serum trypsinogen concentration was significantly elevated in 25 patients with "severe" malnutrition (77.4±42.0 ng/ml, P<0.001) and in 23 with "moderate" malnutrition (55.2±16.1 ng/ml, P<0.02) compared with the mean value (32.5±10.4 ng/ml) for well-nourished controls. The level of circulating trypsinogen tended to rise with increasing severity of malnutrition. There was no relationship between serum trypsinogen and other variables such as age, specific diagnosis, or mode of feeling. Elevated serum trypsinogen levels could not be atributed to renal disease or cystic fibrosis. In patients who showed an improvement in nutritional status, serum trypsinogen tended to revert toward normal. Elevated serum trypsinogen values in acutely malnourished infants and children may results from pancreatic acinar cell damage or regurgitation of enzymes from obstructed pancreatic ducts.
UR - http://www.scopus.com/inward/record.url?scp=0021999191&partnerID=8YFLogxK
U2 - 10.1016/S0022-3476(85)80293-6
DO - 10.1016/S0022-3476(85)80293-6
M3 - Article
AN - SCOPUS:0021999191
SN - 0022-3476
VL - 106
SP - 233
EP - 238
JO - Journal of Pediatrics
JF - Journal of Pediatrics
IS - 2
ER -
