Elevated urinary ADAM12 protein levels in lithium-treated bipolar patients

C. Nadri; Y. Bersudsky; R. H. Belmaker; G. Agam

doi:10.1007/s00702-006-0586-3

Elevated urinary ADAM12 protein levels in lithium-treated bipolar patients

C. Nadri, Y. Bersudsky, R. H. Belmaker, G. Agam

Basic Sciences Divisions

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

ADAM (A Disintegrin And Metalloprotease)12 is a member of a family of integral membrane and secreted glycoproteins. ADAM12 has recently been detected in urine. In the present study we measured ADAM12 protein levels in urine from bipolar patients vs. healthy controls. Nineteen bipolar patients and 22 matched-control subjects were studied. Urine samples were concentrated and Western-blot analysis used to determine ADAM12 protein levels. The 92 kDa form of urine ADAM12 protein levels were highly elevated in Li-treated bipolar patients compared with normal controls. The 68 kDa form of urine ADAM12 protein levels did not differ. Future experiments are needed to explore a potential link between ADAM12 protein level elevation and lithium response.

Original language	English
Pages (from-to)	473-477
Number of pages	5
Journal	Journal of Neural Transmission
Volume	114
Issue number	4
DOIs	https://doi.org/10.1007/s00702-006-0586-3
State	Published - 1 Apr 2007

Keywords

ADAM12
Bipolar disorder
Lithium
Metaloprotease
Oligodendrocytes
Urine

ASJC Scopus subject areas

Neurology
Clinical Neurology
Psychiatry and Mental health
Biological Psychiatry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s00702-006-0586-3

Cite this

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abstract = "ADAM (A Disintegrin And Metalloprotease)12 is a member of a family of integral membrane and secreted glycoproteins. ADAM12 has recently been detected in urine. In the present study we measured ADAM12 protein levels in urine from bipolar patients vs. healthy controls. Nineteen bipolar patients and 22 matched-control subjects were studied. Urine samples were concentrated and Western-blot analysis used to determine ADAM12 protein levels. The 92 kDa form of urine ADAM12 protein levels were highly elevated in Li-treated bipolar patients compared with normal controls. The 68 kDa form of urine ADAM12 protein levels did not differ. Future experiments are needed to explore a potential link between ADAM12 protein level elevation and lithium response.",

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AU - Nadri, C.

AU - Bersudsky, Y.

AU - Belmaker, R. H.

AU - Agam, G.

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N2 - ADAM (A Disintegrin And Metalloprotease)12 is a member of a family of integral membrane and secreted glycoproteins. ADAM12 has recently been detected in urine. In the present study we measured ADAM12 protein levels in urine from bipolar patients vs. healthy controls. Nineteen bipolar patients and 22 matched-control subjects were studied. Urine samples were concentrated and Western-blot analysis used to determine ADAM12 protein levels. The 92 kDa form of urine ADAM12 protein levels were highly elevated in Li-treated bipolar patients compared with normal controls. The 68 kDa form of urine ADAM12 protein levels did not differ. Future experiments are needed to explore a potential link between ADAM12 protein level elevation and lithium response.

AB - ADAM (A Disintegrin And Metalloprotease)12 is a member of a family of integral membrane and secreted glycoproteins. ADAM12 has recently been detected in urine. In the present study we measured ADAM12 protein levels in urine from bipolar patients vs. healthy controls. Nineteen bipolar patients and 22 matched-control subjects were studied. Urine samples were concentrated and Western-blot analysis used to determine ADAM12 protein levels. The 92 kDa form of urine ADAM12 protein levels were highly elevated in Li-treated bipolar patients compared with normal controls. The 68 kDa form of urine ADAM12 protein levels did not differ. Future experiments are needed to explore a potential link between ADAM12 protein level elevation and lithium response.

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KW - Bipolar disorder

KW - Lithium

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KW - Oligodendrocytes

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Elevated urinary ADAM12 protein levels in lithium-treated bipolar patients

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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