Emergence of genetically linked vaccine-originated poliovirus type 2 in the absence of oral polio vaccine, Jerusalem, April to July 2022

Neta S. Zuckerman; Itay Bar-Or; Danit Sofer; Efrat Bucris; Hagar Morad; Lester M. Shulman; Nofar Levi; Leah Weiss; Irina Aguvaev; Zvi Cohen; Klil Kestin; Rinat Vasserman; Michal Elul; Ilana S. Fratty; Miranda Geva; Marina Wax; Oran Erster; Ruth Yishai; Lior Hecht-Sagie; Sharon Alroy-Preis; Ella Mendelson; Merav Weil

doi:10.2807/1560-7917.ES.2022.27.37.2200694

Emergence of genetically linked vaccine-originated poliovirus type 2 in the absence of oral polio vaccine, Jerusalem, April to July 2022

Neta S. Zuckerman
, Itay Bar-Or
, Danit Sofer
, Efrat Bucris
, Hagar Morad
, Lester M. Shulman
, Nofar Levi
, Leah Weiss
, Irina Aguvaev
, Zvi Cohen
, Klil Kestin
, Rinat Vasserman
, Michal Elul
, Ilana S. Fratty
, Miranda Geva
, Marina Wax
, Oran Erster
, Ruth Yishai
, Lior Hecht-Sagie
, Sharon Alroy-Preis

Ella Mendelson, Merav Weil

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

We report an emergence and increase in poliovirus type 2 detection via routine wastewater surveillance in three non-overlapping regions in the Jerusalem region, Israel, between April and July 2022. Sequencing showed genetic linkage among isolates and accumulation of mutations over time, with two isolates defined as vaccine-derived polioviruses (VDPV). This demonstrates the emergence and potential circulation of type 2 VDPV in a high-income country with high vaccine coverage and underscores the importance of routine wastewater surveillance during the polio eradication.

Original language	English
Article number	2200694
Journal	Eurosurveillance
Volume	27
Issue number	37
DOIs	https://doi.org/10.2807/1560-7917.ES.2022.27.37.2200694
State	Published - 15 Sep 2022
Externally published	Yes

ASJC Scopus subject areas

Epidemiology
Microbiology
Immunology and Microbiology (miscellaneous)
Public Health, Environmental and Occupational Health
Microbiology (medical)
Virology
Infectious Diseases

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10.2807/1560-7917.ES.2022.27.37.2200694

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Zuckerman, N. S., Bar-Or, I., Sofer, D., Bucris, E., Morad, H., Shulman, L. M., Levi, N., Weiss, L., Aguvaev, I., Cohen, Z., Kestin, K., Vasserman, R., Elul, M., Fratty, I. S., Geva, M., Wax, M., Erster, O., Yishai, R., Hecht-Sagie, L., ... Weil, M. (2022). Emergence of genetically linked vaccine-originated poliovirus type 2 in the absence of oral polio vaccine, Jerusalem, April to July 2022. Eurosurveillance, 27(37), Article 2200694. https://doi.org/10.2807/1560-7917.ES.2022.27.37.2200694

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title = "Emergence of genetically linked vaccine-originated poliovirus type 2 in the absence of oral polio vaccine, Jerusalem, April to July 2022",

abstract = "We report an emergence and increase in poliovirus type 2 detection via routine wastewater surveillance in three non-overlapping regions in the Jerusalem region, Israel, between April and July 2022. Sequencing showed genetic linkage among isolates and accumulation of mutations over time, with two isolates defined as vaccine-derived polioviruses (VDPV). This demonstrates the emergence and potential circulation of type 2 VDPV in a high-income country with high vaccine coverage and underscores the importance of routine wastewater surveillance during the polio eradication.",

author = "Zuckerman, \{Neta S.\} and Itay Bar-Or and Danit Sofer and Efrat Bucris and Hagar Morad and Shulman, \{Lester M.\} and Nofar Levi and Leah Weiss and Irina Aguvaev and Zvi Cohen and Klil Kestin and Rinat Vasserman and Michal Elul and Fratty, \{Ilana S.\} and Miranda Geva and Marina Wax and Oran Erster and Ruth Yishai and Lior Hecht-Sagie and Sharon Alroy-Preis and Ella Mendelson and Merav Weil",

year = "2022",

month = sep,

day = "15",

doi = "10.2807/1560-7917.ES.2022.27.37.2200694",

language = "English",

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journal = "Eurosurveillance",

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Zuckerman, NS, Bar-Or, I, Sofer, D, Bucris, E, Morad, H, Shulman, LM, Levi, N, Weiss, L, Aguvaev, I, Cohen, Z, Kestin, K, Vasserman, R, Elul, M, Fratty, IS, Geva, M, Wax, M, Erster, O, Yishai, R, Hecht-Sagie, L, Alroy-Preis, S, Mendelson, E & Weil, M 2022, 'Emergence of genetically linked vaccine-originated poliovirus type 2 in the absence of oral polio vaccine, Jerusalem, April to July 2022', Eurosurveillance, vol. 27, no. 37, 2200694. https://doi.org/10.2807/1560-7917.ES.2022.27.37.2200694

TY - JOUR

T1 - Emergence of genetically linked vaccine-originated poliovirus type 2 in the absence of oral polio vaccine, Jerusalem, April to July 2022

AU - Zuckerman, Neta S.

AU - Bar-Or, Itay

AU - Sofer, Danit

AU - Bucris, Efrat

AU - Morad, Hagar

AU - Shulman, Lester M.

AU - Levi, Nofar

AU - Weiss, Leah

AU - Aguvaev, Irina

AU - Cohen, Zvi

AU - Kestin, Klil

AU - Vasserman, Rinat

AU - Elul, Michal

AU - Fratty, Ilana S.

AU - Geva, Miranda

AU - Wax, Marina

AU - Erster, Oran

AU - Yishai, Ruth

AU - Hecht-Sagie, Lior

AU - Alroy-Preis, Sharon

AU - Mendelson, Ella

AU - Weil, Merav

PY - 2022/9/15

Y1 - 2022/9/15

N2 - We report an emergence and increase in poliovirus type 2 detection via routine wastewater surveillance in three non-overlapping regions in the Jerusalem region, Israel, between April and July 2022. Sequencing showed genetic linkage among isolates and accumulation of mutations over time, with two isolates defined as vaccine-derived polioviruses (VDPV). This demonstrates the emergence and potential circulation of type 2 VDPV in a high-income country with high vaccine coverage and underscores the importance of routine wastewater surveillance during the polio eradication.

AB - We report an emergence and increase in poliovirus type 2 detection via routine wastewater surveillance in three non-overlapping regions in the Jerusalem region, Israel, between April and July 2022. Sequencing showed genetic linkage among isolates and accumulation of mutations over time, with two isolates defined as vaccine-derived polioviruses (VDPV). This demonstrates the emergence and potential circulation of type 2 VDPV in a high-income country with high vaccine coverage and underscores the importance of routine wastewater surveillance during the polio eradication.

UR - https://www.scopus.com/pages/publications/85137854455

U2 - 10.2807/1560-7917.ES.2022.27.37.2200694

DO - 10.2807/1560-7917.ES.2022.27.37.2200694

M3 - Article

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AN - SCOPUS:85137854455

SN - 1025-496X

VL - 27

JO - Eurosurveillance

JF - Eurosurveillance

IS - 37

M1 - 2200694

ER -

Emergence of genetically linked vaccine-originated poliovirus type 2 in the absence of oral polio vaccine, Jerusalem, April to July 2022

Abstract

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