Emerging Role of Dysadherin in Metastasis

Kuntal Dey; Haim Garty; Sajal Chakraborti

doi:10.1007/978-3-319-24750-2_11

Emerging Role of Dysadherin in Metastasis

Kuntal Dey
, Haim Garty
, Sajal Chakraborti

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Dysadherin, a small regulator of Na⁺/K⁺-ATPase and a cell membrane glycoprotein, is associated with cancer metastasis. However, its role in metastasis is largely unknown. In this review we highlight the role of this recently identified protein in cancer progression. Dysadherin has been suggested to affect cancer progression by downregulating E-cadherin or by upregulating the chemokine production. Overexpression of dysadherin alters trans epithelial resistance (TER) indicating it’s effect on paracellular permeability. Additional findings suggest that dysadherin also affects extracellular matrix. The expression of dysadherin can influence both the tumor cell as well as the cell matrix. Recent findings strongly suggest that dysadherin expression as an independent prognostic indicator of metastasis. Thus, dysadherin can be used as a molecular target for identification as well as prevention of cancer.

Original language	English
Title of host publication	Advances in Biochemistry in Health and Disease
Publisher	Springer Nature
Pages	185-193
Number of pages	9
DOIs	https://doi.org/10.1007/978-3-319-24750-2_11
State	Published - 1 Jan 2016
Externally published	Yes

Publication series

Name	Advances in Biochemistry in Health and Disease
Volume	15
ISSN (Print)	2512-2142
ISSN (Electronic)	2512-2150

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

CCL2
Cancer
Dysadherin
E-cadherin
FXYD5
Na/K-ATPase
RIC

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology (miscellaneous)
Clinical Biochemistry
Molecular Medicine
Physiology

Access to Document

10.1007/978-3-319-24750-2_11

Cite this

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title = "Emerging Role of Dysadherin in Metastasis",

abstract = "Dysadherin, a small regulator of Na+/K+-ATPase and a cell membrane glycoprotein, is associated with cancer metastasis. However, its role in metastasis is largely unknown. In this review we highlight the role of this recently identified protein in cancer progression. Dysadherin has been suggested to affect cancer progression by downregulating E-cadherin or by upregulating the chemokine production. Overexpression of dysadherin alters trans epithelial resistance (TER) indicating it{\textquoteright}s effect on paracellular permeability. Additional findings suggest that dysadherin also affects extracellular matrix. The expression of dysadherin can influence both the tumor cell as well as the cell matrix. Recent findings strongly suggest that dysadherin expression as an independent prognostic indicator of metastasis. Thus, dysadherin can be used as a molecular target for identification as well as prevention of cancer.",

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author = "Kuntal Dey and Haim Garty and Sajal Chakraborti",

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AU - Dey, Kuntal

AU - Garty, Haim

AU - Chakraborti, Sajal

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PY - 2016/1/1

Y1 - 2016/1/1

N2 - Dysadherin, a small regulator of Na+/K+-ATPase and a cell membrane glycoprotein, is associated with cancer metastasis. However, its role in metastasis is largely unknown. In this review we highlight the role of this recently identified protein in cancer progression. Dysadherin has been suggested to affect cancer progression by downregulating E-cadherin or by upregulating the chemokine production. Overexpression of dysadherin alters trans epithelial resistance (TER) indicating it’s effect on paracellular permeability. Additional findings suggest that dysadherin also affects extracellular matrix. The expression of dysadherin can influence both the tumor cell as well as the cell matrix. Recent findings strongly suggest that dysadherin expression as an independent prognostic indicator of metastasis. Thus, dysadherin can be used as a molecular target for identification as well as prevention of cancer.

AB - Dysadherin, a small regulator of Na+/K+-ATPase and a cell membrane glycoprotein, is associated with cancer metastasis. However, its role in metastasis is largely unknown. In this review we highlight the role of this recently identified protein in cancer progression. Dysadherin has been suggested to affect cancer progression by downregulating E-cadherin or by upregulating the chemokine production. Overexpression of dysadherin alters trans epithelial resistance (TER) indicating it’s effect on paracellular permeability. Additional findings suggest that dysadherin also affects extracellular matrix. The expression of dysadherin can influence both the tumor cell as well as the cell matrix. Recent findings strongly suggest that dysadherin expression as an independent prognostic indicator of metastasis. Thus, dysadherin can be used as a molecular target for identification as well as prevention of cancer.

KW - CCL2

KW - Cancer

KW - Dysadherin

KW - E-cadherin

KW - FXYD5

KW - Na/K-ATPase

KW - RIC

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M3 - Chapter

AN - SCOPUS:105006855340

T3 - Advances in Biochemistry in Health and Disease

SP - 185

EP - 193

BT - Advances in Biochemistry in Health and Disease

PB - Springer Nature

ER -

Emerging Role of Dysadherin in Metastasis

Abstract

Publication series

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

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